Bayer Cropscience S.a.

Norman Dann

Mehul Rasikchandra Amin

Peter Dominic Riordan

Michael Mellor

Peter Riordan

Mehul Amin

Disclosed herein is a process for the preparation of a compound of the formula (II): or a salt thereof, wherein X is halogen; each Y, which may be the same or different, is halogen, haloalkyl, alkoxycarbonyl or alkylsulphonyl, and n is 0 to 3;which process comprises treating a compound of the formula (III): with a cyanide source and a catalyst selected from the group consisting of a tetraalkyl ammonium salt and a tetraalkyl phosphonium salt in an aqueous solvent or without solvent, wherein:X is halogen; each Y, which may be the same or different, is halogen, haloalkyl, alkoxycarbonyl or alkylsulphonyl: and n is 0 to 3; and wherein the cyanide source is hydrogen cyanide, an alkali metal cyanide, an alkaline earth metal cyanide or an optionally substituted ammonium cyanide.

Processes for the preparation of 2-aminomethylpyridines and the 2-cyanopyridines used in their preparation

The invention relates to a process for the preparation of a compound of formula (V), according to the following scheme: wherein the various substituants are as defined in the description

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Cambridgeshire, United Kingdom

Norman Dann