St. Michael's Hospital.

Unity Health Toronto

Norman Comtois

Christer Sinderby

Jennifer Beck

Fredrik Jalde

Pär Emtell

Michael Kock

Giacomo Grasselli

A mechanical ventilation system comprises a plurality of ventilation therapy sub-systems. Each of the ventilation therapy sub-systems is adapted to assist a respiratory function of the patient. The system also comprises a detector of the respiratory drive of the patient, an operator interface receiving one or more control parameters, and a main controller. The main controller assigns a therapeutic contribution to each of the ventilation therapy sub-systems based on the respiratory drive of the patient and on the control parameters. The controller modulates the respiratory drive of a patient by controlling each of the plurality of the ventilation therapy sub-systems according to its assigned therapeutic contribution. Distinct ventilation therapy sub-systems may apply negative pressure on the abdomen of the patient, deliver a non-pressurizing inspiratory flow to the patient, or induce a positive pressure in the airways of the patient.

Systems, devices and methods for modulating a respiratory drive of a patient

A device for providing ventilatory assist to a patient has a manifold having an inspiratory port to receive an inspiratory flow from an inspiratory supply line, an interface port connectable to an external end of an endotracheal tube inserted in a patient's trachea and an expiratory port configured to receive an expiratory flow from the endotracheal tube via the interface port. An inspiratory lumen has a distal end insertable in the endotracheal tube. A cross-section of the inspiratory lumen is smaller than that of the endotracheal tube to allow gas flowing in the endotracheal tube. The inspiratory flow is directed to the inspiratory lumen, or to the endotracheal tube, or at once to the inspiratory lumen and to the endotracheal tube.

Device, method and system for providing ventilatory assist to a patient

A device and method for controlling a level of ventilatory assist applied to a patient by a mechanical ventilator measures, during patient's assisted breath, an inspiratory volume Vproduced by both the patient and the mechanical ventilator, an inspiratory volume Vcontributed by the mechanical ventilator, and an inspiratory assist pressure Pproduced by the mechanical ventilator. A first relation between pressure Pand volume Vand a second relation between pressure Pand volume Vare calculated. Using the first and second relations, a ratio is determined between pressure Pat volume Vand pressure Pat volume V, with volume Vequal to volume V, for a plurality of volumes Vand V. Values of Pare multiplied by the corresponding calculated ratios to calculate a third relation between a predicted inspiratory pressure Pand volume V. The mechanical ventilator is responsive to the third relation to control the level of ventilatory assist.

Device and method for controlling ventilatory assist

The present disclosure relates to a method and a mechanical ventilation system for adjusting a level of ventilatory assist to a patient. A neuro-mechanical efficiency of the patient is determined. A control value is received at the mechanical ventilation system. The level of ventilatory assist to the patient is determined on the basis of the neuro-mechanical efficiency and of the control value. The mechanical ventilation system may be adjusted automatically based on the determined level of ventilatory assist to the patient. Alternatively, the determined level of ventilatory assist to the patient may be displayed for the benefit of an operator and a manual command may be received for adjusting the mechanical ventilation system.

Method and system for adjusting a level of ventilatory assist to a patient

The present disclosure relates to a method and a system for validating inspiratory muscle activity of a patient. Left and right electrical activity signals respectively representing activity of a left muscle and of a right muscle synchronized with an inspiratory effort of the patient are acquired from non-invasive sensors. A cardiac activity signal is extracted from the left and right electrical activity signals. A synchrony, a symmetry or a proportionality of the left and right electrical activity signals from which the cardiac activity signal is extracted is verified. A mechanical ventilation system incorporating the system for validating inspiratory muscle activity of the patient is also disclosed.

Method and system for validating inspiratory muscle activity of a patient, and mechanical ventilation system using the same

The present disclosure relates to a method and a system for quantifying timing discrepancies between inspiratory effort and ventilatory assist. A trigger error is determined by comparing a start time of neural inspiration with a start time of the ventilatory assist. A cycling-off error is determined by comparing an end time of the neural inspiration with an end time of the ventilatory assist. The ventilatory assist is synchronized when the trigger error is lower than a first threshold and the cycling-off error is lower than a second threshold. The ventilatory assist may also be characterized in terms of early or late trigger and of early or late cycling-off. A trigger of a ventilator may be adjusted according to the trigger error and a cycling-off of a ventilator may be adjusted according to the cycling-off error.

Method and system for quantifying timing discrepancies between inspiratory effort and ventilatory assist

A method and device for determining dynamic hyperinflation during mechanical ventilation of a spontaneously breathing patient, wherein mechanical ventilation is removed during one breath of the patient, inspiratory and expiratory volumes of the patient are measured during the one breath, and a difference between the inspiratory and expiratory volumes measured during the one breath is calculated. Dynamic hyperinflation of the patient's lungs is indicated in relation to the calculated difference.

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Scarborough, Canada

Norman Comtois