Amherst Process Instruments, Inc.

Precision Detectors, Inc.

Other

Coulter Electronics of New England, Inc.

Cognoptix, Inc.

On-line Instrumentation, Inc.

Neuroptix Corporation

Metron Instruments, Inc.

Langley-ford Instruments a Division of Coulter Electronics of N.e.

Norman C Ford

Stephen D Fantone

Trent A Poole

Marc David Friedman

Lee E Goldstein

Leo T Chylack, Jr

Evan Sherr

Paul D Hartung

Spencer M Lovette

Barton E Dahneke

Michael G O'Keeffe

Robert E Dion

David K Dueker

Bennie R Ware

Steven D Fantone

Leo T Chylack

A system for performing quasi-elastic light scattering and fluorescent ligand scanning on a subject's eye includes a light source configured to transmit light toward the subject's eye, a lens configured to focus light sent from the source and scattered by the subject's eye, a measurement reflector disposed to receive at least a portion of the focused light and configured to reflect a first portion of the received light, a camera configured and disposed to receive the first portion of the received light and configured to provide indicia of an image corresponding to the first portion of the received light, and a processor coupled to the camera and configured to analyze intensities of light in the image to determine a location of a reference point corresponding to an interface of a portion of the eye.

Ocular imaging

Methods and apparatus are provided for measuring component concentration in a liquid containing relatively large particles and relatively small particles. The invention may be utilized for measuring fat and casein concentrations in a dairy product, but is not limited to such use. A polarized light beam is directed through a scattering cell having first and second windows and containing a sample of the liquid. A normal to an exterior surface of the second window of the scattering cell is at or near Brewster's angle with respect to the light beam to reduce or eliminate reflections. A first light detector, positioned at an angle of about 5&deg; to about 45&deg; with respect to the light beam, detects scattered light from a first component of the liquid, such as fat particles. A second light detector, positioned at an angle of about 130&deg; to about 160&deg; with respect to the light beam, detects scattered light from a second component of the liquid, such as casein particles. When the liquid is a dairy product, the detector signals are representative of fat and casein concentrations. Component concentrations of a dairy product may be measured without requiring the use of a chemical diluent.

Measurement systems and methods for determining component particle concentrations in a liquid

A high temperature light scattering measurement device for characterizing certain physical properties of molecules is described. In one embodiment the device includes a sample scattering chamber having at least one detector positioned about the chamber so as to collect light scattered by the molecules to be characterized located within the sample chamber. The sample scattering chamber, detectors and associated optics are located within an oven to maintain the scattering chamber at an elevated temperature. Light to be scattered by molecules in the sample scattering chamber is provided by a laser located outside the oven. Light from the laser is directed along an optical path through the oven wall where it is then focussed by optical elements on the sample chamber.

High temperature light scattering measurement device comprising a rigid

A molecular characterization detector includes a scattering cell containing a sample for molecular characterization, a light source for directing a light beam through the cell so that the light beam is scattered by the sample, optical elements for selecting from the scattered light a measurement beam comprising light that is scattered by the sample from a predetermined portion of the cell in a predetermined range of angles relative to the optical axis, and a detector for detecting the measurement beam and providing an output electrical signal representative of the measurement beam. The detector typically selects light scattered from a central portion of the scattering cell at angles in the range of 14.degree. to 16.degree.. A single spherical lens is preferably utilized. As a result, interference from stray scattered light is minimized. A beam dump attenuates the light beam after it passes through the scattering cell. Additional detectors detect light scattered at 90.degree. to the light beam. The outputs of the detectors are processed to provide molecular characterization of the sample.

Methods and apparatus for molecular characterization

Apparatus, intended primarily for use in an aerodynamic particle sizing system, for generating a pair of closely-spaced, substantially parallel light beams and for determining particle sizes by measuring the times of flight of particles between the two light beams. The apparatus for generating the light beams includes a laser source, an aperture slit for establishing the shape of the beams, a cylindrical lens for focusing the laser beam on the aperture slit, a diffraction grating for converting the beam from the aperture slit into diffracted beams in the zero order lobe and one first order lobe and a transfer lens for directing the diffracted beams as substantially parallel beams. The particle measuring apparatus includes a prism, a lens arrangement for imaging light scattered by particles passing through one beam on a first face of the prism and for imaging light scattered by particles passing through the other beam on a second face of the prism that is perpendicular to the first face, and a pair of photomultiplier tubes for detecting light reflected by the faces of the prism. Start and stop pulses from the photomultiplier tubes are processed to determine particle time-of-flight which is then converted to particle size.

Beam forming and sensing apparatus for aerodynamic particle sizing system

Apparatus, intended primarily for use in an aerodynamic particle sizing system, for generating a pair of closely-spaced light beams, each having a thin, elongated cross-sectional shape. Particle sizes are determined by directing a particle stream through the light beams and measuring the times of flight of particles between the two light beams. The apparatus for generating the light beams includes a laser source and beam forming optics. In one embodiment, a first light beam is formed at the particle stream by a cylindrical lens. After passing through the particle stream, the first light beam is reflected and focused to form a second light beam at the particle stream that is displaced from the first light beam. The first light beam can be reflected and focused by a concave cylindrical mirror or, alternatively, by a flat mirror and a convex cylindrical lens. In another embodiment, the incident light beam from the laser source is passed through a diffraction grating which provides a zero order lobe and a first order lobe. The zero order lobe and the first order lobe are focused at a particle stream by a cylindrical lens to form the first and second beams.

Beam forming apparatus for aerodynamic particle sizing system

Multichannel electrophoresis apparatus employing electrophoretic light scattering as a means for characterizing the particles under study. The apparatus is characterized by the ability to measure light scattered simultaneously using a plurality of local oscillators incident at different angles from the same population of particles being subjected to electrophoresis. The apparatus is used with data processing means to analyze the large amount of scattering data which provide information on electrophoretic mobility, particle size, particle charge, electrophoretic mobility, zeta potential. An important aspect of the new apparatus is a markedly improved capability to segregate data related to diffusion effects from data relating to heterogeneous effects.

Electrophoretic light scattering with plural reference beams, apparatus

A light scattering interfacial tension spectrometer has a laser source of light directed, as an incident beam I.sub.i, through a focusing lens and a diffraction grating. The grating divides the incident beam I.sub.i into a main beam I.sub.m, undiffracted light, and a higher order, diffracted light, reference beam I.sub.r. The beam I.sub.r is passed through an attenuator and a diffraction focusing lens to a region under test, such as a liquid surface. The main beam I.sub.m, from the grating is transmitted through the common diffraction focusing lens to the test region where it is reflected. The reference beam I.sub.r is reflected from the test surface together with scattered light I.sub.s, and directed through an aperture to a photomultipler tube. The output of the photomultiplier is coupled to a pulse amplifier-discriminator and a photon correlator. For a liquid surface under test the output of the spectrometer provides a measure of the surface tension and the viscosity of the liquid.

Light scattering apparatus and method

Method and apparatus are disclosed for measuring contaminants in aqueous humor without rupturing an examined eye. The apparatus includes a laser which projects a light beam through a gonioscopic lens into the aqueous humor of the examined eye. The light is scattered in the humor with a portion of the scattered light being reflected by the gonioscopic lens to an analyzing system. The system measures the diffusion constant of any contaminant in the aqueous humor and, by comparing the diffusion constant to a set of known diffusion constants, determines the composition of the macromolecules or the cells of the contaminant.

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Amherst, MA, United States of America

Norman C Ford