New England Nuclear Corporation

Norman Adler

Leopoldo Lazaro Camin

Paul Gold

A technetium-99m-stannous-phosphate complex in which the phosphate moiety includes pyrophosphate and in which no more than 5 to 15% or 20% by weight of such phosphate moiety is a linear polyphosphate of molecular weight greater than pyrophosphate, a method of making the same, a method of using the same by in vivo intravenous administration to a mammal of the sterile, nonpyrogenic complex followed by radioassay scanning or imaging the skeletal structure, and a kit made up of a stannous-phosphate complex in which the phosphate moiety is pyrophosphate and in which no more than 5 to 15% or 20% by weight of such phosphate moiety is a linear polyphosphate of molecular weight greater than pyrophosphate.

Bone seeking technetium 99m complex

Radionuclide diagnostic agents, comprising technetium-99m, a reducing agent, preferably a stannous reducing agent, and certain polyhydroxycarboxylic acids and derivatives thereof, i.e. glucoheptonic acid, lactobionic acid, galacturonic acid and glucuronic acid and salts thereof, are highly useful, both in the study and diagnosis of kidney morphology and function, and in the diagnosis of ischemic, infarcted or diseased tissue.

Growing community of inventors

Arlington, MA, United States of America

Norman Adler