Coulter Corporation

Other

University of Miami

Converge Biotech Inc.

Norma Sue Kenyon

Olavi Siiman

Wade E Bolton

Camillo D Ricordi

John A Maples

Cynthia G Healy

Jeffrey Alan Hubbell

Nicholas S Bodor

Thomas R Russell

Luca Inverardi

Christopher A Fraker

Paolo Serafini

Antonello Pileggi

Peter Buchwald

Robert K Zwerner

Robert J Schmittling

Angel Kaifer

Fabio Grassi

Vance Paul Lemmon

Paul Latta

Bonnie Beth Blomberg

Cheryl Stabler Anderson

Pirouz Mohammad Daftarian

Raquibul Chowdhury

A device () for receiving implanted biological material includes a mechanoprotective surface () defining an adjacent space, an assembly () for locally delivering media to said space, and a pump or slow/sustained release reservoir structure () operatively coupled to the assembly. The device may comprise an additional plunger body for being disposed in said space. The implanted biological material may be encapsulated or non-encapsulated.

Therapeutic hybrid implantable devices

A cell population or subpopulation enrichment procedure for separating undesired populations or subpopulations from a biological sample utilizing relatively heavy, dense particles and gravity sedimentation. The particles have one or more reactants bound thereto which are specific to and will bind with the selected population or subpopulation to be eliminated from the sample. The particles preferably are mixed with the sample by repeatedly causing the particles to settle through a substantial portion of the sample to bind to the selected population. The particles with the bound selected population to be eliminated then are allowed to preferentially settle in the sample and the supernatant including the enriched population or subpopulation is separated from the particles with the population to be eliminated bound thereto. The enriched population supernatant can then be analyzed, utilized as is, have other populations or subpopulations removed or have additional amounts of remaining cells of the previously eliminated populations removed in additional steps.

Method and apparatus for bulk enrichment of a population or

The invention provides a method for enriching a sample in tumor cells and determining the DNA ploidy and proliferative index of the tumor cells present in the sample. The method uses a pan-leukocyte monoclonal antibody conjugated to a separable substrate such as magnetic microspheres to conjugate and remove leukocytes from the sample. A fluorescently labelled monoclonal antibody specific to a tumor associated antigen or an antigen arising from the presence of the tumor and a DNA staining reagent are added to the leukocyte depleted sample. The sample is then analyzed by dual color flow cytometry to determine cells having an abnormal DNA content by gating on fluorescently labelled cells.

Method of analyzing tumor cell DNA content through tumor cell enrichment

The invention describes the use of novel aminodextran compounds containing about 5-20% by weight amine groups to bind a plurality of monoclonal antibodies. The resulting antibody-aminodextran compounds may be used to induce the activation and proliferation of selected mammalian cells. Specific examples are given using an anti-CD3 monoclonal antibody conjugated two aminodextrans containing about 5% and 16%, respectively, by weight amine groups as an agent for inducing the activation and proliferation of T cells.

Anti-CD3 antibody-aminodextran conjugates for induction of T-cell

Growing community of inventors

Miami, FL, United States of America

Norma Sue Kenyon