Pfizer Corporation

Norma Jacqueline Tom

John Charles Kath

Samit Kumar Bhattacharya

Eric David Cox

Joel Morris

Zhengyu Liu

David C Whritenour

Michael J Castaldi

John Michael Humphrey

David B Ripin

The present invention relates to a process for preparing a compound of the formula I or a pharmaceutically acceptable salt, prodrug, hydrate or solvate thereof, wherein R, R, Rand Rare as defined herein. The compound of formula I is useful in the treatment of abnormal cell growth, such as cancer, in mammals.

Processes for the preparation of benzoimidazole derivatives

A process for interconverting a mixture of cis-trans isomers of a compound of formula I into the substantially pure cis isomer. Cis isomers of formula I are useful intermediates in the synthesis of cis isomers of benzamide piperidine compounds which exhibit activity as NK-1 receptor antagonists.

Process for converting a cis-trans mixture of substituted benzylidene amines into the pure cis isomer

The invention relates to compounds of the formula 1and to pharmaceutically acceptable salts and solvates thereof, wherein A, X, R, Rand Rare as defined herein. The invention also relates to methods of treating abnormal cell growth in mammals by administering the compounds of formula 1 and to pharmaceutical compositions for treating such disorders which contain the compounds of formula 1. The invention also relates to methods of preparing the compounds of formula 1.

Heteroaromatic bicyclic derivatives useful as anticancer agents

The present invention relates to a process for preparing pyridazinone aldose reductase inhibitors which are useful in the prevention and/or treatment of diabetic complications such as diabetic neuropathy, diabetic retinopathy, diabetic nephropathy, diabetic cardiomyopathy, diabetic microangiopathy and diabetic macroangiopathy in mammals. The invention also relates to novel intermediates useful in preparing those aldose reductase inihibitors.

Process and intermediates for pyridazinone antidiabetic agents

Methods of making quinoline amides

Substituted bicyclic derivatives useful as anticancer agents

Methods of preparing NHE-1 disclosed. The NHE-1 inhibitors are useful for the reduction of tissue damage resulting from tissue ischemia.

Method for preparing sodium-hydrogen exchanger type 1 inhibitor

The invention relates to compounds of the formula 1

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Waterford, CT, United States of America

Norma Jacqueline Tom