Taiho Pharmaceutical Company Limited

Kuraray Co., Ltd.

Noriyuki Yamamoto

Hirofusa Ajioka

Takashi Nishida

Masakazu Fukushima

Yutaka Mizushima

Koichi Kanehira

Michio Terasawa

Rie Igarashi

Norihiko Suzuki

Kenzo Arizono

Keiko Hoshi

Masahito Komuro

Masayuki Inoue

Manzo Shiono

Makoto Kajitani

Shozo Yamada

Shingo Yano

Tomoyasu Ohno

Kosuke Fujiwara

The present invention provides an agent for alleviating side effects caused by use of an anti-tumor agent, which contains 5-chloro-6-(2-iminopyrrolidin-1-yl)methyl-2,4(1H,3H-pyrimidi nedione (1) represented by formula (1): or a pharmaceutically acceptable salt thereof. The 5-chloro-6-(2-iminopyrrolidin-1-yl)methyl-2,4(1H,3H)-pyrimidinedione or a pharmaceutically acceptable salt thereof exhibit an inflammatory-suppressing action in the digestive tract and advantageously alleviate diarrhea and loss of body weight concomitant with administration of a chemical for treating cancer without suppressing the anti-tumor effect. Thus, the compounds of the present invention are of great value as agents for alleviating side effects caused by use of an anti-tumor agent, which enable not only the chemotherapy to be continuedly carried out, but also the body exhaustion to be effectively prevented.

Agents for alleviating side effects

Benzothiadiazine derivatives

11.beta.,17.alpha.,21-Trihydroxy-1,4-pregnadiene-3,20-dione 21-[(E,E)-3,7,11-trimethyl-2,6,10-dodecatrienoate] of the formula ##STR1## an antiinflammatory composition thereof and a method for the production thereof. 11.beta.,17.alpha.,21-Trihydroxy-1,4-pregnadiene-3,20-dione 21-[(E,E)-3,7,11-trimethyl-2,6,10-dodecatrienoate] of the present invention exhibits remarkably excellent antiinflammatory action and besides, displays reduced side effects and can be produced in high selectivity and good yield and conveniently.

11-beta, 17-alpha, 21-trihydroxy-1, 4-pregnadiene-3, 20 21-[(E-E)-3,7,

11.beta., 17.alpha.,21-trihydroxy-1,4-pregnadiene-3,20-dione

Growing community of inventors

Tokushima, Japan

Noriyuki Yamamoto