Yamasa Corporation

Kyoto University

Noriyuki Ashida

Shinji Sakata

Haruhiko Machida

Eiichi Kodama

Kazuki Endo

Masao Matsuoka

Yuichi Yoshimura

Mikari Watanabe

To provide a novel anti-psychosocial stress agent which is highly safety and can be continuously taken, more particularly, a novel anti-psychosocial stress agent which prevents or alleviates psychosocial stress. The invention provides an anti-psychosocial stress agent containing, as an active ingredient, uridylic acid, uridine, or uracil. Since uridylic acid, uridine, or uracil, which is an active ingredient of the anti-psychosocial stress agent of the present invention, is inexpensively available and is a biological component, the agent exhibits high safety and can be continuously taken. Therefore, the anti-psychosocial stress agent of the present invention is effective for mitigating, alleviating, or relieving psychosocial stress, which is an issue in modern society. When the anti-psychosocial stress agent is taken before development of symptoms associated with psychosocial stress, the symptoms can be prevented. The anti-stress effect of the agent is superior to that of GABA, which has become of interest and has been incorporated into, for example, foods.

Agent against psychosocial stresses

The present invention provides a novel purine 4'-thioarabinonucleoside represented by the following formula �1!: ##STR1## wherein B represents a purine base other than adenine. Also disclosed are a method for preparing the purine 4'-thioarabinonucleoside and pharmaceutical compositions containing the purine 4'-thioarabinonucleoside.

Purine 4'-thioarabinonucleosides

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Choshi, Japan

Noriyuki Ashida