Eisai Company, Limited

Eisai Ci., Ltd.

Noriyasu Hirose

Shigeru Souda

Shizuo Kuriyama

Norio Minami

Kenji Hayashi

Chiaki Seki

Hidetoshi Kawashima

Kouzou Morita

Hiroshi Inoue

Takashi Yoshimura

Noriyoshi Iwata

Yuh Horikawa

Toshio Matsunami

Shizumasa Kijima

Kazutoshi Miyake

Yasuhiro Akiyama

Kimio Hamamura

Takashi Banba

Kiiti Ema

Kazuyasu Usuki

Tetsuya Nakamura

Yuichi Inai

Takaharu Nakamura

Kiyomi Yamatsu

Naoko Nagaoka

Noritoshi Sano

Yuko Miyauchi

Yuuichi Inai

Naoko Sakabe

Akifumi Kitahara

Takeshi Uzuo

A process is provided for the preparation of .alpha.-tocopherol. According to the process, a condensation reaction between trimethylhydroquinone and a specific phytol derivative or isophytol is conducted in the presence of any one of the following solvents:

Process for the preparation of .alpha.-tocopherol

2,3,5-trimethyl-benzoquinone is produced by oxidizing 2,3,6-trimethyl-phenol in the presence of a catalyst of cupric chloride and lithium chloride in a solvent mixture of an aromatic hydrocarbon and a lower aliphatic alcohol having 1 to 4 carbon atoms.

Process for preparing 2,3,5-trimethylbenzoquinone

The novel vitamin E derivative provides an excellent antihyperlipemic effect and is defined by the formula (I): ##STR1## wherein R represents a nicotinoyl group; and m is an integer of from 2 to 5 while n is an integer of from 3 to 6, provided that n is larger than m.

Novel vitamin E derivatives and process for the production thereof

A carboximide derivative represented by the general formula: ##STR1## wherein X is ##STR2## Z is alkyl, aralkyl, cycloalkyl, cycloalkylalkyl, alkenyl or arylalkenyl, and Y is a substituted or unsubstituted pyridyl, pyrimidyl or phenyl group, and a pharmaceutically acceptable acid addition salt thereof. The carboximide derivative and acid addition salt are useful for treating diabetes and also for depressing the central nervous system. The carboximide derivative may be produced by reacting a sodium alkoxide represented by the general formula: ##STR3## wherein X and Y have the same meanings as defined above, with Z.Hal wherein Hal is a halogen and Z has the same meaning as defined above.

Carboximide derivative and medicines containing same

New phenothiazine derivatives having the general formula: ##STR1## wherein R represents a straight or branched alkyl group or alkenyl group having 5-15 carbon atoms, their acid addition salts and anti-psychotic drugs containing such new compounds.

Phenothiazine derivatives and anti-psychotic drugs containing the same

The carboximide derivatives of the formula: ##STR1## and pharmaceutically acceptable salts thereof; wherein X represents a group of the formula: ##STR2## Z represents a hydrogen atom or a group of the formula: ##STR3## wherein R represents an alkyl group, an aralkyl group, an aryl group, a cycloalkyl group, an alkenyl group, an arylalkenyl group, a pyridyl group or a substituted amino group; Y represents an alkyl group, an aralkyl group, an aryl group, a substituted or unsubstituted pyridyl group, a substituted or unsubstituted pyrimidyl group or a benzothiazolyl group; and m represents an integer of 2 or 3 and processes for the production thereof. The derivatives and their salts possess hypoglycemic activity and are useful for treating diabetes.

Piperazine substituted carboxamide derivatives, compositions and method

Novel phenethylamine derivatives represented by the general formula: ##STR1## wherein R is a lower alkyl group, C.sub.n H.sub.2n is a branched or straight alkylene group, A is a phenyl group unsubstituted or substituted with hydroxy, a lower alkoxy or a lower alkylene dioxy group, and n is an integer from 1 to 4, and pharmacologically acceptable acid addition salts thereof, and bronchdilator containing the same. These bronchdilator have an intense and durable bronchdilating effect and a weak heart stimulating action.

Novel phenethylamine derivatives and bronchdilator containing the same

Novel phenethylamine derivatives represented by the general formula: ##STR1## wherein R is a lower alkyl group, C.sub.n H.sub.2n is a branched or straight alkylene group, A is a phenyl group unsubstituted or substituted with hydroxy, a lower alkoxy or a lower alkylene dioxy group, and n is an integer from 1 to 4, and pharmacologically acceptable acid addition salts thereof, and bronchdilator containing the same. These bronchdilator has an intense and durable bronchdilating effect and a weak heart stimulating action.

Phenethylamine derivatives and bronchdilator containing the same

New phenothiazine derivatives having the general formula: ##STR1## wherein R represents hydrogen atom or a lower alkyl group, and A represents a lower alkylene group, and process for the production thereof. The phenothiazine derivatives have remarkable activities against the central nervous system, and are useful as psychotropic drugs.

Psychotropic

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Tokyo, Japan

Noriyasu Hirose