Sankyo Company, Limited

Noritoshi Kitano

Yasuhiro Morisawa

Mitsuru Kataoka

Toshiaki Matsuzawa

Junya Ide

Fusao Kondo

Akira Endo

Kazuo Sato

Anthony Cornelius O'Sullivan

Akira Terahara

Toshiaki Yanai

Shigeki Muramatsu

Akira Ogiso

Bruno Frei

Akio Torikata

Keijiro Ishibashi

Mamoru Arai

Akira Nishida

Seiji Mitsui

Kenichi Kusano

Hisayoshi Fukatsu

Toshiaki Mastuzawa

Isao Seki

Yasuo Nakada

Derivatives of milbemycins D, A.sub.3 and A.sub.4 and of the corresponding sec-butyl compound have a halogen atom at the 13-position; at the 5-position, they have an oxygen (keto) atom, an oxime group or a substituted oxime group. They may be prepared from known compounds by any appropriate combination of halogenation, ketonization and oximation.

13-Halomilbemycin derivatives, their preparation and compositions

5-Carbonate derivatives of milbemycins A.sub.3, A.sub.4 and A.sub.5 have valuable acaricidal, anthelmintic and other activities, especially against endo- and exoparasites.

Milbemycin 5-carbonate derivatives and compositions containing them

Oxime derivatives of 5-didehydromilbemycins A.sub.3, A.sub.4 and D are represented by the formula: ##STR1## (wherein R.sup.1 represents methyl, ethyl or isopropyl, and R.sup.2 represents hydrogen, lower alkyl, optionally substituted aralkyl or --CH.sub.2 COOR.sup.3, wherein R.sup.3 represents hydrogen or lower alkyl). These and their salts and esters have valuable anthelmintic, acaricidal and insecticidal activity.

5-Oxime derivatives of milbemycins and veterinary and agricultural use

Anthelmintic composition and the use thereof

ML-236B carboxylic acid derivatives having the formula ##STR1## wherein R represents an alkyl group, a benzyl group optionally substituted with alkyl, alkoxy or halogen or a phenacyl group optionally substituted with alkyl, alkoxy or halogen; a group of 1/n M in which M represents a metal and n represents a valency of said metal; or a group of AH.sup.+ in which A represents an amino acid. These derivatives are derived from ML-236B by conventional procedures and have an antihyperlipemic activity.

ML-236B carboxylic acid derivatives and their use as antihyperlipemic

Pyridine derivatives having the formula ##STR1## wherein R.sub.1 is an alkyl group having 1 to 3 carbon atoms; R.sub.2 is hydrogen atom or an alkyl group having 1 to 3 carbon atoms; R.sub.3 is hydrogen atom, an alkyl group having 1 to 4 carbon atoms, an alkenyl group having 3 or 4 carbon atoms, an alkyl group having 1 or 2 carbon atoms and hydroxy as a substituent, an alkanoyl group having 1 to 18 carbon atoms, an alkenoyl group having 3 to 11 carbon atoms, an aromatic acyl group having 6 or 10 carbon atoms in the aromatic ring and optionally alkyl, alkoxy, acetylamino, cyano or halogen as a substituent, a heterocyclic acyl group, an alkylcarbamoyl group having 1 to 4 carbon atoms in the alkyl moiety, an allylcarbamoyl group or hydroxy group; n is an integer of 0 to 2 inclusive; and, when n is 2, R.sub.1 's may be the same or different; provided that when R.sub.2 is said alkyl group having 1 to 3 carbon atoms, R.sub.3 is said alkyl group having 1 to 4 carbon atoms. They are highly effective in the treatment of coccidiosis.

Pyridine derivatives and their use as anticoccidial agents

Pyridine derivatives having the formula ##STR1## wherein R.sub.1 represents hydrogen atom, amino group or a group ##STR2## in which R.sub.5 and R.sub.6 may be the same or different and each represents an alkyl group of 1 to 4 carbon atoms or R.sub.5 is hydrogen atom and R.sub.6 represents an alkyl group of 1 to 4 carbon atoms, an alkenyl group of 3 or 4 carbon atoms or a benzyl group optionally substituted with halogen, cyano, alkyl of 1 to 4 carbon atoms or alkoxy of 1 to 4 carbon atoms;

Pyridine sulfonamides and their use as anticoccidial agents

Use of dithiocarbamic acid derivatives having the structure ##STR1## in which R.sub.1, R.sub.2 and R.sub.3 are various organic radicals as preventive and curative agents against mycoplasmosis. These derivatives are prepared from the starting materials having the structure ##STR2## by reaction with carbon disulfide or from the starting materials having the structure ##STR3## BY REACTION WITH R.sub.3 -halide.

Preventive and curative compositions against mycoplasmosis

Anticoccidial compositions which comprise as active ingredient pyridine derivatives having the formula ##STR1## wherein R.sub.1 is hydrogen atom, a halomethyl group or methyl group;

Compositions and methods for the treatment of coccidiosis

An anticoccidial composition which comprises a compound of the formula ##SPC1## Intimately dispersed in an inert edible carrier, wherein R.sub.1 and R.sub.2 are each hydrogen, an aliphatic acyl group, an aromatic acyl group or a heterocyclic acyl group, and at least R.sub.1 and R.sub.2 is said heterocyclic acyl group; or a salt thereof. The composition is a preventive and curative anticoccidial agent for poultry and domestic animals. Particularly, it shows a significant activity against chronic coccidiosis caused by Eimeria acervulina. The composition is less toxic for animals, besides it has an advantage that it is also effective for coccidiosis caused by coccidia resistant to the known anticoccidial agents.

Substituted pyridinol-containing compositions and methods for the

Fungicidal compositions for topical treatment of dermatomycosis of animals which contain as active ingredient an antibiotic substance siccanin, preferably in the form of an aerosol or an ointment.

Fungicidal compositions for dermatomycosis of animals

Antibiotic substance named 'Pholipomycin' which is useful as a growth promoting agent for domestic animals, poultries and the like and produced by the cultivation of a new microorganism, Streptomyces lividoclavatus strain No. 3176, NRRL 8022.

New antibiotic substance, its preparation and its use as growth

A composition which comprises a pyridinol derivative of the formula ##SPC1## Intimately dispersed in an inert edible carrier, wherein R.sub.1 and R.sub.2 may be the same or different and each represents a hydrogen atom; a lower alkyl group, an aralkyl group, an aliphatic, an aromatic or a heterocyclic acyl group; an alkoxycarbonyl group; an aralkoxycarbonyl group; an aryloxycarbonyl group; a N-substituted carbonyl group; a N-substituted thiocarbonyl group; a phosphono group; or a salt thereof. The composition is a preventive and curative anticoccidial agent for poultry and domestic animals. Particularly, it shows a significant activity against chronic coccidiosis caused by Eimeria acervulina. The composition is less toxic for animals, besides it has an advantage that it is also effective for coccidiosis caused by coccidia resistant to the known anticoccidial agents.

Growing community of inventors

Tokyo, Japan

Noritoshi Kitano