Toyama Chemical Co., Ltd.

Taisho Pharmaceutical Co., Ltd.

Noritomo Fujino

Toru Yamaguchi

Naoya Ono

Fumihito Ushiyama

Tetsuya Tanikawa

Yasunobu Ushiki

Yasuhiro Tsutsui

Nobuhiko Nomura

Hiroshi Nishikawa

Risa Tsuruta

Ayumu Mori

Keiko Yamamoto

An amidine compound represented by formula (I) (wherein Arepresents a nitrogen atom or a group represented by formula CR; Aand Aare the same as or different from each other and independently represent a nitrogen atom or a group represented by formula CH; Rrepresents an aryl group which may be substituted by 1 to 5 substituents independently selected from a substituent group (2) or the like; Rand Rare the same as or different from each other and independently represent a hydrogen atom, a halogen atom, a Calkyl group, a Chaloalkyl group or a Calkoxy group; and Rand Rare the same as or different from each other and independently represent a hydrogen atom, a Chaloalkyl group, a Calkyl group or the like) or a salt thereof. The compound is useful as an anti-fungal agent.

Amidine compound or salt thereof

A pharmaceutical composition containing one or more antifungal agents selected from an arylamidine derivative represented by the general formula: (wherein Rrepresents an amidino group that may be substituted with a hydroxyl group that may be protected with an acyl group, an amidino group that may be substituted with an alkoxy group that may be substituted, or an amidino group that may be substituted with an aralkyloxy group that may be substituted; Rand Ridentically or differently represent a hydrogen atom or a halogen atom) or a salt thereof, an azole antifungal agent, a polyene antifungal agent, a candin antifungal agent and a fluoropyrimidine antifungal agent has a strong antifungal activity and is useful for the treatment of fungal infection. A method for using them in combination is useful as an excellent therapeutic method for fungal infection. A pharmaceutical composition containing the arylamidine derivative represented by the above general formula or a salt thereof and an immunosuppressant has a strong antifungal activity and is useful for the treatment of fungal infection and a skin disease such as atopic dermatitis. A method for using them in combination is useful as an excellent therapeutic method for fungal infection and a skin disease such as atopic dermatitis.

Pharmaceutical composition and method using antifungal agent in combination

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Toyama, Japan

Noritomo Fujino