Sumitomo Chemical Company, Limited

Noritaka Hanma

Takenari Nakagome

Ikutaro Saji

Kaoru Maeshima

Masataka Fukumura

Yasuo Motoike

Renzo Sato

An optically active imidazolylpropanol compound of the formula: ##STR1## wherein n is an integer of 3 or 4, and its acid addition salts, which is useful as an antifungal agent, prepared by reacting an imidazolylthiol of the formula: ##STR2## with an alkylating agent of the formula:

Process for preparing optically active imidazolylpropanol compounds, and

A process for producing a compound of the formula (I) ##SPC1## wherein R.sub.2 is a hydrogen atom or an ester protective group, which is useful as a precursor for the production of cephalosporin derivatives, comprising reacting a phosphoramide derivative of cephalosporin of the formula (II) ##SPC2## wherein R.sub.1 is a lower alkyl group and R.sub.2 is as defined above, with a phosphorus acid. A further embodiment includes preparing the phosphoramide derivative of cephalosporin of the formula (II) by reactng a compound of the formula (III) ##SPC3## wherein R.sub.1 and R.sub.2 are as defined above, with an acid compound.

Process for producing cephalosporins

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Sakai, Japan

Noritaka Hanma