Takeda Chemical Industries, Inc.

Hitachi, Ltd.

Norio Tada

Yoshiaki Kato

Akio Miyake

Katsumi Itoh

Yoshinobu Yoshimura

Yoshikazu Oka

Kouzi Onishi

An apparatus for directly connecting an analytical column and a mass spectrometer comprising a fixed member having at least four holes which respectively introduce washing solution, eluate containing a component eluted from the analytical column, desalting solution and eluent for eluting the component, and a movable member rotated with respect to an axis having at least four tubes around the axis and mounting the four trapping columns, whereby the trapping columns are respectively washed, trapped, desalted and eluted in parallel. Furthermore, a common trapping column may be used instead of the four trapping columns by controlling the apparatus with four analytical modes.

Apparatus for directly coupling analytical column with mass spectrometer

New isochroman derivatives which may be represented by general formula [I] ##STR1## wherein R.sup.1 is hydrogen atom, a lower alkoxy group or hydroxyl group and R.sup.2 is a lower alkoxy group or hydroxyl group; R.sup.1 and R.sup.2 may also be, connecting with each other, alkylenedioxy group; R.sup.3 is a hydrogen atom, a lower alkyl or aralkyl group and R.sup.4 is a lower alkyl or aralkyl group; R.sup.3 and R.sup.4 may also be groups which, taken together with the adjacent nitrogen atom, form a cyclic amino group; n means 1 or 2, and pharmacologically acceptable salt thereof have antidepressant, analgesic, diuretic, anti-inflammatory, muscle relaxing, vasodilator, hypotensive and other pharmacologic activities for mammals.

Isochroman derivatives

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Ikeda, Japan

Norio Tada