Zaidan Hojin Biseibutsu Kagaku Kenkyu Kai

Mercian Corporation

Sanraku-ocean Co., Ltd.

Sanraku Incorporated

Norio Shibamoto

Takeo Yoshioka

Hamao Umezawa

Tomio Takeuchi

Toshikazu Oki

Hiroshi Naganawa

Taiji Inui

Masaaki Ishizuka

Tomoyuki Ishikura

Rokuro Okamoto

Yasuo Fukagawa

Yoshio Watanabe

Masataka Shirai

Hiroshi Tone

Naoki Agata

Shin-ichi Hirano

Kaichiro Kominato

Hitosi Agematu

Hiroshi Iguchi

Hiroyuki Chiba

Hiroshi Nishida

Toshihiko Kumamoto

Rei Kaneto

Tomoyuki Kioka

Yutaka Hara

Masaaki, All Ishizuka

Antibiotic Mer-AF1032A represented by the following formula (I) and its isomer antibiotic Mer-AF1032B are disclosed. Also disclosed are a method for preparing the antibiotics comprising the cultivation of a strain belonging to genus Penicillium and a pharmaceutical composition comprising one of these antibiotics and useful as an antifungal agent. ##STR1##

Antibiotics Mer-AF1032A and Mer-AF1032B

4-Hydroxypyridine derivative represented by the following formula ##STR1## wherein R represents a methyl group or an isopropyl group, and the method for preparing the derivative comprising the step of cultivating a strain belonging to Streptomyces karnatakensis are disclosed. Also disclosed are the pharmaceutical composition comprising the same and a method for treating circulatory diseases comprising the step of administering said compound to a patient.

4-hydroxypyridine derivatives, useful for treating circulatory diseases

Compounds represented by formula ##STR1## wherein Y.sup.1 and Y.sup.2 are identical or different, and respectively denote benzoylamino groups or phthalimide groups. This compound is useful for inhibition of dipeptidase.

Aminoethylcysteine derivatives

An aminocarboxylic acid derivative represented by the formula ##STR1## wherein R.sub.1 and R.sub.2, independently from each other, represent a hydrogen atom or an alkyl group which may have a substituent, and Y represents --NH-- or --S--, provided that when Y represents --NH--, at least one of R.sub.1 and R.sub.2 represents an alkyl group which may have a substituent. These compounds have excellent inhibitory activity on dipeptidase in animals, and are useful for administration in combination with carbapenem antibiotics.

Aminocarboxylic acid derivatives

New antitumor agents designated MA 144-M.sub.1 and MA 144-M.sub.2, which are anthracycline glycosides and inhibit the growth of gram-positive bacteria, e.g. Staphyococcus aureus, Bacillus subtilis and Sarcina lutea, and inhibit the growth of animal tumors such as leukemia L 1210, P 388 and sarcoma 180 are produced by fermentation of MA 144-producing strains of streptomyces and by the chemical or enzymatic conversion of aclacinomycin A or cinerubin A.

Process for producing antibiotics MA 144-M.sub.1 and MA 144-M.sub.2

New antitumor agents designated MA 144-M.sub.1 and MA 144-M.sub.2, which are anthracycyline glycosides and inhibit the growth of gram-positive bacteria, e.g. Staphyococcus aureus, Bacillus subtilis and Sarcina lutea, and inhibit the growth of animal tumors such as leukemia L 1210, P 388 and sarcoma 180 are produced by fermentation of MA 144-producing strains of streptomyces and by the chemical or enzymatic conversion of aclacinomycin A or cinerubin A.

Process for preparing antibiotics MA 144-M.sub.1 and MA 144-M.sub.2

New antitumor agents designated MA 144-M.sub.1 and MA 144-M.sub.2, which are anthracycline glycosides and inhibit the growth of gram-positive bacteria, e.g. Staphyococcus aureaus, Bacillus subtilis and Sarcina lutea, and inhibit the growth of animal tumors such as leukemia L 1210, P 388 and sarcoma 180 are produced by fermentation of MA 144-producing strains of streptomyces and by the chemical or enzymatic conversion of aclacinomycin A or cinerubin A.

Antitumor antibiotics MA 144-M.sub.1 and MA 144-M.sub.2

Growing community of inventors

Chigasaki, Japan

Norio Shibamoto