Takeda Chemical Industries, Inc.

Norio Okutani

Osamu Nishimura

Masato Suenaga

Akira Haze

Hiroaki Ohmae

Tsuneo Asano

Kunihiro Ito

A method for removing from a peptide the diketone of the methionine residue, and a method for manufacturing a peptide or salt thereof which does not possess an N-terminal methionine residue, characterized by having a peptide or salt thereof which possesses a diketone of the optionally oxidized N-terminal methionine residue react with 3,4-diaminobenzoic acid or a salt thereof in the presence of acetic acid and sodium formate, formic acid and sodium formate, or formic acid and sodium acetate.

Process for eliminating N-terminal methionine

There is disclosed a process for producing purified xanthan gum, which comprises (i) adding a hydrophilic organic solvent to an aqueous solution containing crude xanthan gum with pH 0.5 to 2.5, and (ii) neutralizing the mixture with a base to precipitate the xanthan gum. The xanthan gum thus obtained has low contents of ash and remaining organic solvent, as well as a high quality with little impurities, and can advantageously be used in the fields of foods, cosmetics, medicaments and the like.

Process for producing purified xanthan gum

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Hyogo, Japan

Norio Okutani