Toray Industries, Inc.

Zaidan Hojin Biseibutsu Kagaku Kenkyu Kai

Seiko Instruments & Electronics Ltd.

Norio Kawabe

Hiromi Uchiro

Teruo Nakadate

Masatoshi Ito

Keijiro Takanishi

Masahiko Tanahashi

Masaji Ohno

Takao Aoki

Kouichi Tsuruta

Takamasa Harada

Koji Iwasa

Seiji Okazaki

Shu Matsumoto

Kokichi Ito

Hiroyuki Ikeuchi

Mikio Tsuda

Kazuo Hosoi

Takashi Fujita

Yuriko Funaba

Mutsuo Kataoka

Takao Kinashi

Yuriko Kawai

Teiji Kawano

Ryuichi Haruta

Sadao Kobashi

Drugs for periodontal disease

Method of producing bis(4-alkylthiophenyl) disulfides

Process for production of methanediphosphonic acid compound

The present invention relates to a methanediphosphonate derivative, its manufacturing process, and pharmaceutical applications, that is represented with the following formula: ##STR1## wherein, D is either sulfur, oxygen, NH, alkyl-substituted N, CH.sub.2, or SCH.sub.2, X represents an alkyl group, alkyl group having a hetero atom as a substitution group, an aryl group or an acyl group, m represents an integer of 1 to 5, and R.sup.1, R.sup.2, R.sup.3 and R.sup.4 independently represent hydrogen, alkyl groups having 1 to carbon atoms or pharmaceutically allowable cations. .function.The compounds of the present invention have excellent IL-1 inhibitory action, antioxidation action and bone resorption inhibitory action, and are useful as antiinflammatory agents, antirheumatic agents, bone metabolic disease drugs, autoimmune disease drugs, or osteoporosis drugs.

Pharmaceutical applications for methanediphosphonate derivative

Methanediphosphonic acid derivative, process for production thereof and

Methane diphosphonic acid derivative, its production process and its

The present invention relates to a methanediphosphonate derivative, its manufacturing process and pharmaceutical applications, that is represented with the following formula: ##STR1## (wherein, B is either hydrogen, an alkyl group, hydroxyl group, alkoxy group or amino group, D is either sulfur, oxygen, NH, alkyl-substituted N, CH.sub.2 or SCH.sub.2, X represents an alkyl group, alkyl group having a hetero atom as a substitution group, an aryl group or an acyl group, m represents an integer of 1 to 5, and R.sup.1, R.sup.2, R.sup.3 and R.sup.4 independently represent hydrogen, alkyl groups having 1 to 7 carbon atoms or pharmaceutically allowable cations). The compound of the present invention has excellent IL-1 inhibitory action, antioxidation action and bone resorption inhibitory action, and is useful as an antiinflammatory agent, antirheumatic, bone metabolic disease drug, autoimmune disease drug, osteoporosis drug and so forth.

Methanediphosphonate derivative, its manufacturing process and its

Methylenediphosphonic acid compounds and methods of use for the

Disclosed is a liquid crystal element with an improved orientation layer and a coating composition for forming such an orientation layer. The orientation layer consists essentially of a polymer with a Mark-Houwink coefficient of not less than 0.85, the Mark-Houwink coefficient being represented by the formula [I]:

Liquid crystal element

A process for preparing a thin film having a large area. A casting solution of a film-forming material and a solvent is fed to the surface of a liquid substrate immiscible with the solution by utilizing interfacial tension. Spontaneous spreading of the casting solution occurs across the surface of the liquid substrate and evaporation of the solvent produces a thin film on the liquid surface which is continuously collected. The feed of the casting solution to the surface of the substrate is at least either a material which shows selective wettability for the casting solution in preference to the liquid substrate or a structure capable of developing capillarity.

Process for preparing a thin film

An image-forming laminated plate, particularly a dry planographic printing unprocessed plate, comprising a base substrate, a photosensitive layer containing a substance with quinonediazide structure and a silicone rubber layer in laminating order is treated with a base after imagewise exposure. In addition, the image-forming laminated plate may be subjected to a whole surface slight exposure to the extent that 5 to 60 molar % of the quinonediazide structure in the photosensitive layer to be exposed is photo-decomposed into carboxylic acid structure before or after the usual imagewise exposure for obtaining a negative working plate, or the image-forming laminated plate may be subjected to a imagewise slight exposure to the same extent without the usual imagewise exposure for obtaining a positive working plate. The base-treatment alone or in combination with the slight exposure enhances both the adhesion of the photosensitive layer to the silicone rubber layer and the solvent resistance of the photosensitive layer in non-image areas.

Treatment of image-forming laminated plate

Provided is a presensitized planographic printing master plate requiring no dampening water for use in negative work which comprises a base substrate, a light releasing photosensitive layer overlying the base substrate and a silicone rubber layer overlying the photosensitive layer. When the printing master plate is exposed through a negative film and then treated with a developer, only the silicone rubber layer overlying the exposed photosensitive layer is removed, while the photosensitive layer remains as it is to form an image area. Dampening water is not required when printing is carried out.

Dry planographic printing plate and preparation thereof

High purity cis-epoxysuccinic acid and salts thereof are economically and systematically prepared by contacting an aqueous solution, obtained by reacting a maleic acid salt and hydrogen peroxide in the presence of a tungstate or molybdate catalyst under a specified condition, with a strongly basic Type II anion exchange resin.

Process for preparing CIS-epoxysuccinic acid salts of high purity

As new compound, a series of 2-hydrocinnamoyl-1,3-cyclopentanedione derivative of the general formula: ##STR1## WHEREIN Ar stands for a mono-valent aromatic radical, for example, phenyl and 3,4-methylenedioxy-phenyl, substituted or unsubstituted, have been found to have an activity to inhibit the action of tyrosine hydroxylase and to be useful as hypotensive agent. These new compounds may be produced by condensing 2-acetyl-1,3-cyclopentanedione with an aromatic aldehyde of the formula Ar-CHO wherein Ar is as defined, according to Claisen-Schmidt condensation, followed by the hydrogenation of the condensation product obtained, or the new compounds may also be produced by reacting 2-acetyl-1,3-cyclopentanedione with an aromatic halide of the formula Ar-CH.sub.2 X wherein Ar is as defined and X is a halogen, for example, in liquid ammonia and in the presence of an alkali metal amide.

2-Hydrocinnampyl-1,3-cyclopentanediones

Growing community of inventors

Kanagawa, Japan

Norio Kawabe