Meiji Seika Kaisha, Ltd.

Norio Ezaki

Yujiro Yamada

Tomizo Niwa

Takashi Shomura

Shinji Miyadoh

Shoichi Amano

Shigeharu Inouye

Michio Kojima

Tatsuo Ito

Takashi Tsuruoka

Yasuaki Ogawa

Chuhei Nojiri

Jiro Itoh

Mitsugu Itoh

Taro Niida

Masao Koyama

Masaji Sezaki

Eiichi Akita

Kazunori Ohba

Takashi Hisamatsu

Shinji Miyado

Keinosuke Miyauchi

Kunikazu Totsugawa

Saeko Takahashi

Harumi Fukuyashu

Mitsugu Ito

Antibiotic, designated as pyrrolomycin E is described, and which is obtained by cultivating an pyrrolomycin E - producing strain belonging to the genus Streptomyces, for example, Streptomyces sp. SF-2080 (FERM-P No. 5072, ATCC No. 31673), in a nutrient medium, and recovering pyrrolomycin E from the culture which contains also other antibiotic substances (pyrrolomycin A, B, C and D) together with the desired substance.

Antibiotic pyrrolomycin E

An antibiotic SF-2103A substance or a salt thereof, and a process for the production thereof are described, and the process comprises cultivating an antibiotic SF-2103A substance-producing strain in a nutrient medium and recovering the desired substance from the culture broth.

Antibiotic SF-2103A substance and process for production thereof

Disclosed is a novel antibiotic SF-2107 series substance consisting essentially of Substance SF-2107 A-1, Substance SF-2107 B and/or Substance SF-2107 C, each having the phisico-chemical properties as described in the specification, which substance exhibits an antibacterial activity against both gram-positive and gram-negative bacteria and is useful for pharmaceuticals, bactericides, disinfectants, etc. Also disclosed is a process for preparing the substance.

Novel antibiotic SF-2107 series substance and process for preparing the

Antibiotics, designated as SF-2080A substance and SF-2080B substance, are described, and are obtained by cultivating an SF-2080 substance-producing strain belonging to the genus Streptomyces, for example, Streptomyces sp. SF-2080 (FERM-P No. 5072, ATCC No. 31673), in a nutrient medium, and recovering the desired substance from the culture.

Antibiotic substances and processes for production thereof

A novel antibiotic BN-235 substance and a process for making it are described, wherein the hydrochloride thereof has the following properties:

Novel antibiotic BN-235 substance, and process for the production thereof

A novel antibiotic designated BN-183B substance is disclosed which is produced by cultivating a strain of the genus Pseudomonas. The antibiotic has a strong action against Gram-positive and Gram-negative bacteria.

Novel antibiotic, BN-183B substance

A BN-213 substance-producing strain of the genus Pseudomonas is cultivated to produce BN-213 substance in a culture medium. The BN-213 substance is isolated from the culture medium and purified, and proved to be a novel antibiotic.

Novel antibiotic BN-213 substance and its production

New antibiotics, SF-2050 substance and SF-2050B substance are produced by cultivating a microorganism Streptomyces sp. SF-2050 now deposited under FERM-P 4358 and under ATCC. 31450 in a liquid culture medium under aerobic conditions, and these antibiotics may be isolated from the fermentation broth and useful as an antibacterial agent. These antibiotics have an activity inhibitory to .beta.-lactamase.

Antibiotics SF-2050 and SF-2050B substances and production and use

An antibiotic BN-200 substance produced by cultivating a BN-200 substance strain of the genus Erwinia and a process for producing the BN-200 substance.

Antibiotic BN-200 substance and process for production thereof

A new antibiotic designated BN-130 substance is now provided, which has antibacterial activity against gram-negative and gram-positive bacteria as well as acid-fast bacteria. BN-130 substance is produced by cultivating a strain of Pseudomanas stutzeri under aerobic conditions.

Growing community of inventors

Yokohama, Japan

Norio Ezaki