Toyama Chemical Co., Ltd.

Norio Abe

Isao Watanabe

Tsutomu Kodama

Yutaka Kodama

Hiroshi Hirano

Hirotoshi Arai

Takuya Kodama

Masaakira Senoura

Masao Nakabayashi

Tomonobu Yamaguchi

Katsunori Tanaka

Akira Takai

Katsufumi Tanaka

A novel 2-[4-(3-methyl-2-thienyl)phenyl]propionic acid and a pharmaceutically acceptable salt thereof. These compounds are useful for treating symptoms of inflammation and pain in mammals including man. This disclosure relates to such compounds, a process for producing the same, a pharmaceutical composition containing such a compound and a method for treating symptoms of inflammation and pain.

Novel 2-[4-(3-methyl-2-thienyl)phenyl]propionic acid and

Novel sym.-triazines having the formula: ##EQU1## wherein R.sup.1 is a substituted or unsubstituted alkyl, alkenyl, cycloalkyl, cycloalkylalkyl, aralkyl or heterocyclic alkyl group; R.sup.2 is a hydrogen atom or a substituted or unsubstituted alkyl, alkenyl, cycloalkyl, cycloalkylalkyl, aryl, aralkyl or heterocyclic alkyl group; and Z.sup.1 and Z.sup.2, which may be the same or different, each represents oxygen or sulfur, have a central nerve inhibitory activity, an anti-inflammatory activity, an analgesic activity and a sedative activity, and can be prepared by reacting a 2,4-dichloro-6-substituted sym.-triazine with a compound having the formula HO--R.sup.2 in which R.sup.2 is the same as defined above.

Sym.-triazine carbamates

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Toyama, Japan

Norio Abe