Otsuka Pharmaceutical Company, Limited

Educational Foundation Jichi Medical University

Norimitsu Hariguchi

Makoto Matsumoto

Hiroshi Shimizu

Isao Takemura

Yoshihiro Goto

Masanori Kawasaki

Shigeto Yoshida

Yoshikazu Kawano

Yoshio Ohba

Shunpei Ishikawa

Masami Mizukoshi

Masahiro Saito

Motohiro Itotani

Yoshikazu Haraguchi

Yukitaka Uematsu

Katsuya Inagaki

Kuniko Hirota

Atsunori Kaneshige

Yohei Hayashi

Toshio Shinohara

Yuya Nakai

Miki Matsuba

The purpose of the present invention is to provide a compound having excellent antibacterial activity against, multidrug-resistant tuberculosis bacteria, and/or non-tuberculous acid-fast bacteria. A compound represented by formula [I]: (in the formula, each symbol is as described in the attached specification), or a salt thereof can be used to diagnose, prevent, and/or treat tuberculosis.

Piperidine derivative

It is an object of the present invention to provide a compound having an excellent antibacterial activity against tuberculosis bacteria, multidrug-resistant tuberculosis bacteria and/or non-tuberculous mycobacteria. Disclosed is a compound of the general formula (1): wherein each symbol is defined as described in the attached specification, or a salt thereof.

Heterobicyclic compounds and their use for the treatment of tuberculosis

The present invention provides a novel transfer vector and a recombinant baculovirus; methods for the production thereof; pharmaceuticals containing the recombinant baculovirus as an active ingredient, which are useful as preventive or therapeutic drugs for infectious diseases such as malaria and influenza; and methods for preventing and treating infectious diseases such as malaria and influenza. More specifically, the invention provides a recombinant transfer vector capable of expressing a foreign gene fused to a virus gene under the control of a dual promoter; a recombinant baculovirus; methods for the production thereof; pharmaceuticals containing the recombinant baculovirus as an active ingredient; and methods for preventing and treating infectious diseases such as malaria and influenza comprising administrating the recombinant baculovirus to patients.

Recombinant baculovirus vaccine

A recombinant transfer vector capable of expressing a foreign gene fused to a viral gene under the control of dual promoters and a recombinant baculovirus, and methods for production thereof, as well as pharmaceuticals comprising the recombinant baculovirus as an active ingredient.

Growing community of inventors

Osaka, Japan

Norimitsu Hariguchi