Hokkaido University

Mochida Pharmaceutical Co., Ltd.

Norimasa Iwasaki

Nobuo Ohzawa

Akio Minami

Tatsuya Igarashi

Daisuke Kawamura

Mariko Imai

Yasuhiko Kasahara

Tomohiro Onodera

Hitoshi Mizuno

Toshiya Endo

Tomokazu Takai

Koji Iwasaki

Chihiro Miyajima

Fumiyoshi Kasahara

Satoshi Shimizu

Akira Takahashi

Masahiko Katayama

Mitsuko Isaji

Hideki Sudo

Eiji Kondo

Yasuyuki Kawaguchi

Wooyoung Kim

Atsushi Sukegawa

Shinichi Sakaue

Kuniyoshi Masuda

Takeru Tsujimoto

Daisuka Kawamura

Realized is reliable fixation of a material in a fluid state containing a monovalent metal salt of alginic acid when the material is applied to a subject. A combination of compositions comprising a first material composition containing a monovalent metal salt of alginic acid and a second material composition containing a cross-linking agent having an action of cross-linking the monovalent metal salt of alginic acid, wherein the combination is to be used in such a way as to apply the first material composition to a subject in a fluid state and contact the second material composition with the first material composition applied to the subject to gel at least a part of the first material composition, wherein the first material composition further contains a coloring component so that a formation state of a gel coat on a surface of the first material composition applied to the subject can be evaluated.

Combination and method for treating subject using alginate

The present invention provides a composition for filling the nucleus pulposus of an intervertebral disc, the composition containing a low endotoxin monovalent metal salt of alginic acid. The composition is applied to a nucleus pulposus site of a subject, is used so as to be cured partially after application, and has fluidity when applied to the nucleus pulposus site. Accordingly, a composition for filling nucleus pulposus is provided, the composition being capable of promoting the regeneration of the nucleus pulposus of an intervertebral disc.

Composition for treating intervertebral disc

A retractor is provided that can form a joint cavity internal space for a field of view for an endoscope and practice of a treatment in a state where a wound area is spread. A retractor includes first arm portionsandand a second arm portionpositioned between the first arm portionsand. The first arm portionsandinclude first claw portionsandto be hung on a wound area entrance edge. The second arm portionincludes a second claw portionto be hung on the wound area entrance edge. When the first arm portionsandand the second arm portionare in a closed state, the first claw portionsandand the second claw portionoverlap with each other.

Retractor

The present invention has an objective of providing a novel composition for treating a fibrocartilaginous tissue injury. The present invention provides a composition for treating a fibrocartilaginous tissue injury, which is to be applied to an injured fibrocartilaginous tissue part of a target and which comprises a monovalent metal salt of alginic acid, more preferably a low endotoxin monovalent metal salt of alginic acid.

Composition for treating fibrocartilage tissue damage

A novel composition for regenerating a cartilage has been demanded, which can achieve a good effect of regenerating a hyaline cartilage that is a nearly normal cartilage without requiring the use of any transplanted cell. The present invention provides a composition for regenerating a cartilage, wherein (a) a monovalent metal salt of low endotoxin alginic acid and (b) SDF-1 are used in combination.

Method for regenerating cartilage comprising applying a monovalent metal salt of alginic acid and SDF-1

The present invention provides a composition for regenerating cartilage or treating a cartilage disease containing a monovalent metal salt of alginic acid for which the endotoxin level thereof has been lowered to an extent that does not substantially induce inflammation or fever. As a result, it is possible to provide a composition for regenerating cartilage that improves cartilage regenerative action and ease of application to a cartilage injury lesion, and a composition for treating a cartilage disease, which has the effects of protecting cartilage from mechanical irritation, inhibiting degenerative changes in cartilage caused by wear and inflammation, repairing a cartilage injury lesion, and inhibiting inflammation and pain of joint tissue.

Method for regenerating hyaline cartilage

Compositions and methods for treating cartilage disease

The present invention provides compositions and methods for treating a joint disease containing as an active ingredient thereof a monovalent metal salt of alginic acid for which the endotoxin level thereof has been lowered to an extent that does not substantially induce inflammation or fever. As a result, it is possible to provide a composition for treating a joint disease which has the effects of protecting cartilage from mechanical irritation, inhibiting degenerative changes in cartilage caused by wear and inflammation, repairing cartilage injuries, suppressing inflammation and pain of joint tissue, inhibiting degeneration of synovial tissue, and inhibiting osteochondral destruction.

Composition for treating arthritic disorder

Growing community of inventors

Hokkaido, Japan

Norimasa Iwasaki