Sysmex Corporation

Noriko Yokose

Kenta Noda

Masatoshi Suganuma

Naoki Nishiyama

Disclosed is a method for determining sensitivity to a CDK4/6 inhibitor, comprising the steps of: comparing a value based on activity of at least one CDK selected from CDK4 and CDK6 in a sample collected from a subject, with a threshold level corresponding to the CDK, and determining that the subject is insensitive to the CDK4/6 inhibitor when the value based on the CDK activity is less than the threshold level.

Method for determining sensitivity of cyclin-dependent kinase 4/6 inhibitor

Disclosed is a cyclin-dependent kinase substrate including a polypeptide that contains an amino acid sequence represented by formula (1): R&#x2014;P (wherein Rrepresents a serine residue or a threonine residue, P represents a proline residue, '&#x2014;' represents a single bond, and the left side represents the N-terminal side), and satisfies the following (a1) and/or (b1): (a1) the second amino acid residue counting from the proline residue toward the N-terminal side in the formula (1) is an aromatic amino acid residue, and/or (b1) at least two amino acid residues from the proline residue toward the C-terminal side in the formula (1) are acidic amino acid residues.

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Kobe, Japan

Noriko Yokose