University of Washington

Nakano Vinegar Co., Ltd.

Japan Immunoresearch Laboratories Co., Ltd.

Noriko Takahashi

Sen-Itiroh Hakomori

Cho-chou Kuo

Albertina F Swanson

Masakazu Adachi

Yoshiya Kawamura

Yoji Arata

Yoshinori Tsukamoto

Koichi Sato

Masahiro Fujimori

Nobuo Shimoda

Masashi Mizokami

Akihiro Aizawa

Hideko Ishihara

Hiroaki Nakagawa

Chizu Ishida

Katsunari Tezuka

Hiroyuki Ohsuga

Hiroyuki Hanzawa

Tetsuya Kibe

Kazuo Yoshioka

Oligosaccharides specific formediate attachment of the organism to host cells.

Chlamydia oligosaccharides

[object Object]

The present invention relates to a novel clinical examination method which comprises analyzing the alteration in the amount of a specific component in oligosaccharides of immunogloblin G. Human diseases such as liver diseases, malignant hypertension, immunogloblin A-nephropathy, pediatric disorders, etc., are examined in terms of the alteration in bisecting N-acetylglucosamine-containing oligosaccharides in immunogloblin G from collected humor. The present invention provides highly accurate information in a manner applicable to practical operation for examination of liver diseases, allergic diseases, malignant hypertension, immunogloblin A nephropathy, pediatric disorders, as well as aging-dependent variations and the therapeutic effect of interferon.

Method for clinical examination based on the structures of immunoglobin

A sugar chain of the following formula is disclosed. ##STR1## It can be prepared by separating glycoproteins from cell membrane components by using lectins which recognize the sugar chain, releasing the sugar chain structure from the glycoproteins, and purifying the released sugar chain. The sugar chain is useful for the diagnosis and treatment of cancer.

Sugar chain

Growing community of inventors

Nagoya, Japan

Noriko Takahashi