Kao Corporation

Noriko Ito

Shigeru Moriwaki

Michiyo Sasajima

Tsutomu Fujimura

Yoshinori Takema

Akira Yamamuro

Minoru Nagai

Mitsuyoshi Sakasai

Toshiya Ono

Azumi Nagasawa

Megumi Matsuoka

Chie Fuse

The present invention provides a method for evaluating or screening a hair growth-regulating agent which utilizes a readily available animal. The present invention is directed to a method for evaluating or screening a hair growth-regulating agent which comprises subjecting hair follicles of a pig to an organ culture in the presence of a test substance, and evaluating or selecting a substance which promotes or suppresses the growth of the hair follicles.

Method for evaluating or screening hair growth-regulating agent

To provide a drug, an external use composition, and a cosmetic composition, which exhibit an NFAT signal inhibitory action, a calcineurin inhibitory action, and a hair growth-promoting effect. The NFAT signal inhibitor contains, as an active ingredient, American angelica or an extract thereof.

NFAT signal inhibitor and calcineurin inhibitor

Wrinkling modifiers

The invention relates to wrinkling modifiers and anti-aging cosmetic compositions which each comprise a guanidine derivative represented by the following general formula (1):

Method of modifying wrinkles using guanidine derivatives

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Tochigi, Japan

Noriko Ito