Kanoncure, Inc.

Tottori University

National University Corporation Tottori University

Noriko Itaba

Goshi Shiota

Minoru Morimoto

Hiroki Shimizu

Kenichiro Abe

Hiroyuki Oka

Yohei Kouno

Keita Kanki

Tomohiko Sakabe

Shinya Kunita

Kenzo Seto

Zyunya Adumi

Satoshi Yokogi

Yohei Kono

A novel therapeutic drug for malignant tumors, cancer stem cells, or fibrosis is obtained. A therapeutic drug for malignant tumors or cancer stem cells is used that includes at least one compound selected from the group consisting of compounds represented by formulas (1), (2), and (5), a salt thereof, or a solvate thereof. Alternatively, a therapeutic drug for fibrosis can be used that includes at least one compound selected from the group consisting of compounds represented by formulas (1), (2), and (5), a salt thereof, or a solvate thereof.

Inhibitory effect of low molecular weight compound on cancer and fibrosis

[Problem] To provide a composition and a cell sheet which are highly effective for inhibiting fibrosis, or cells having fibrosis-inhibiting activity, which are useful in regenerative medicine. [Solution] A medium containing IC-2 or a related compound is inoculated with mesenchymal stem cells or bone marrow mononuclear cells, and the cells are cultured for a prescribed period of time while the IC-2 or related compound is maintained at a constant concentration, thereby allowing a composition and a cell sheet which are highly effective for inhibiting fibrosis, or cultured cells having fibrosis-inhibiting activity, to be obtained.

Fibrosis-inhibiting composition, cells producing same, and cell sheet comprising said cells

To obtain a novel therapeutic drug for a malignant tumor or fibrosis. Used is a compound represented by formula (1), a salt thereof, or a solvate thereof. Also used is a therapeutic drug for a malignant tumor or a therapeutic drug for fibrosis, comprising a compound represented by formula (1), a salt thereof, or a solvate thereof.

Suppression and regeneration promoting effect of low molecular weight compound on cancer and fibrosis

Growing community of inventors

Yonago, Japan

Noriko Itaba