Shionogi Company Limited

Shionogi Seiyaku Kabushiki Kaisha

Norihiko Tanimoto

Michio Masuko

Hideyuki Takenaka

Yoshio Hayase

Toshio Takahashi

Mitsuhiro Ichinari

Takahiro Kataoka

Moriyasu Masui

Masanao Inagaki

Yoshiharu Hiramatsu

Kuniyoshi Nishida

Yasushi Hasegawa

Nobuhiro Haga

Tsunetoshi Honma

Akinori Arimura

Susumu Mitsumori

Toshihiko Takahashi

A compound having CRTH2 receptor antagonism, represented by the following formula (I). The compound is useful for the treatment of allergic diseases having a relation to eosinophils and the like. A compound of the formula (I): whereina group represented by the formula: is a group represented by the formula: and the like, Ris carboxy and the like, Ris &#x2014;(CH)n-N(&#x2014;Y)&#x2014;SO&#x2014;Ar and the like, the other symbols are as defined in claim

Indole arylsulfonaimide compounds exhibiting PGD 2 receptor antagonism

A compound of the formula (I): wherein A is alkylene optionally having an unsaturated bond; R is &#x2014;C(&#x2550;O)&#x2014;R; Ris hydroxy or the like; m is 0 or 1; p is 0 or 1; Xand Xare each independently optionally substituted aryl or optionally substituted heteroaryl or the like; Xis a bond, &#x2014;CH&#x2014;, &#x2014;S&#x2014;, &#x2014;SO&#x2014;, &#x2014;CH&#x2014;O&#x2014;, &#x2014;O&#x2014;CH&#x2014;, &#x2014;CH&#x2014;S&#x2014;, &#x2014;S&#x2014;CH&#x2014;, or the like; Xis &#x2014;CH&#x2014;, &#x2014;CH&#x2014;CH&#x2014;, &#x2014;C(&#x2550;O)&#x2014;, or the like, having a dual antagonistic activity against both a thromboxane Areceptor and a prostaglandin Dreceptor is found.

[object Object]

Compounds of the general formula (I) which are metabolically stable and have an antagonistic activity against PGDreceptor:&#x2003;wherein Y is bicyclic ring; Ris optionally substituted heteroaryl; Ris hydrogen, etc.; Ris &#x2014;CH&#x2014;CH&#x2014;CH&#x2014;CH&#x2014;CH&#x2550;CH&#x2014;COOR, &#x2014;CH&#x2014;CH&#x2014;CH&#x2014;CH&#x2014;X&#x2014;CH&#x2014;COOR, &#x2014;CH&#x2014;CH&#x2550;CH&#x2014;CH&#x2014;X&#x2014;CH&#x2014;COORor &#x2014;CH&#x2014;CH&#x2014;CH&#x2014;COOR; Ris hydrogen, etc.; Xis &#x2014;O&#x2014;, etc.

PGD2 receptor antagonistic pharmaceutical compositions

Tricyclic compound

Compounds having fungicidal activities and represented by general formula (I) and salts and hydrates thereof

Oxime derivatives, hydrazone derivatives and use thereof

A fungicidal composition for agricultural use, which comprises a compound of the formula: ##STR1## wherein R.sup.1 and R.sup.2 are each hydrogen, lower alkyl or cyclo(lower)alkyl; R.sup.3 is lower alkyl or cyclo(lower)alkyl; R.sup.4 and R.sup.5 are each hydrogen, lower alkyl, lower alkoxy, halogen-substituted lower alkyl, lower alkyl-substituted silyl, halogen or nitro; A represents an unsaturated hydrocarbon group, a halogen-substituted unsaturated hydrocarbon group, a phenyl group or a heterocyclic group, among which the phenyl group and the heterocyclic group may be optionally substituted with not more than three substituents; and Z is --CH.sub.2 --, --CH(OH)--, --CO--, --O--, --S--, --NR-- (R being hydrogen or lower alkyl), --CH.sub.2 CH.sub.2 --, --CH.dbd.CH--, ##STR2## --CH.sub.2 O--, --CH.sub.2 S--, --CH.sub.2 SO--, --OCH.sub.2 --, --SCH.sub.2 -- or --SOCH.sub.2 --.

Process for the preparation of alkoxyiminoacetamide derivatives and

A fungicidal composition for agricultural use, which comprises a compound of the formula: ##STR1## wherein R.sup.1 and R.sup.2 are each hydrogen, lower alkyl or cyclo(lower)alkyl; R.sup.3 is lower alkyl or cyclo(lower)alkyl; R.sup.4 and R.sup.5 are each hydrogen, lower alkyl, lower alkoxy, halogen-substituted lower alkyl, lower alkyl-substituted sibyl, halogen or nitro; A represents an unsaturated hydrocarbon group, a halogen-substituted unsaturated hydrocarbon group, a phenyl group or a heterocyclic group, among which the phenyl group and the heterocyclic group may be optionally substituted with not more than three substituents; and Z is --CH.sub.2 --, --CH(OH)--, --CO--, --O--, --S--, --NR-- (R being hydrogen or lower alkyl), --CH.sub.2 CH.sub.2 --, --CH=CH--, ##STR2## --CH.sub.2 O--, --CH.sub.2 S--, --CH.sub.2 SO--, --OCH.sub.2 --, --SCH.sub.2 -- or --SOCH.sub.2 --.

Alkoxyiminoacetamide derivative

Alkoxyiminoacetamide derivatives and their use as fungicides

There is disclosed a compound of the formula (I): ##STR1## wherein X is a hydrogen atom or 1 to 5 substituents which may be the same or different and are selected from the group consisting of a hydrogen atom, alkyl, alkenyl, alkynyl, optionally substituted phenyl, an optionally substituted heterocyclic group, alkoxy, alkenyloxy, alkynyloxy, optionally substituted phenoxy, mono-, di- or tri-substituted halogenoalkyl and a halogen atom; Y is CH or N; m is 0 or 1; A is a group of the formula: ##STR2## (wherein R.sup.1 is a hydrogen atom or alkyl; n is 0 or 1; B is O, S or NR.sup.3 ; R.sup.2 and R.sup.3 are the same or different and are a hydrogen atom, alkyl, alkenyl, alkynyl, phenyl, benzyl, acyl or phenacyl). There are also disclosed the production thereof and an agricultural fungicide containing the compound as an active component.

Phenylmethoxyimino compounds and agricultural fungicides containing them

A fungicidal composition for agricultural use, which comprises a compound of the formula: ##STR1## wherein R.sup.1 and R.sup.2 are each hydrogen, lower alkyl or cyclo(lower)alkyl; R.sup.3 is lower alkyl or cyclo(lower)alkyl; R.sup.4 and R.sup.5 are each hydrogen, lower alkyl, lower alkoxy, halogen-substituted lower alkyl, lower alkyl-substituted silyl, halogen or nitro; A represents an unsaturated hydrocarbon group, a halogen-substituted unsaturated hydrocarbon group, a phenyl group or a heterocyclic group, among which the phenyl group and the heterocyclic group may be optionally substituted with not more than three substituents; and Z is --CH.sub.2 --, --CH(OH)--, --CO--, --O--, --S--, --NR-- (R being hydrogen or lower alkyl), --CH.sub.2 CH.sub.2 --, --CH.dbd.CH--, --CH.sub.2 O--, --CH.sub.2 S--, --CH.sub.2 SO--, --OCH.sub.2 --, --SCH.sub.2 -- or --SOCH.sub.2 --. ##STR2##

Growing community of inventors

Koka, Japan

Norihiko Tanimoto