Tokyo Tanabe Company, Ltd.

Norihiko Kakehi

Naoto Matsuishi

Toshio Kawashima

Shigeki Omura

Michiaki Amano

Yoshio Nakagawa

Pyrido[1,2-a]pyrimidine derivatives of the general formula [I] and their physiologically acceptable salts are provided: ##STR1## where R is a hydrogen atom, a halogen atom or a methyl group, and n is a whole number of 0, 1 or 2. The pyrido[1,2-a]-pyrimidine derivatives and their salts exhibit an excellent antagonistic effect on slow-reacting substance of anaphylaxis and, therefore, are useable for the treatment of allergic diseases.

Tetrazolyl-substituted pyrido[1,2-a]pyrimidines and use as SRS-A

Pyrido[1,2-a]pyrimidine derivatives of the general formula [I] and their physiologically acceptable salts are provided: ##STR1## where R is a hydrogen atom, a halogen atom or a methyl group, and n is 0, 1 or 2. The pyrido[1,2-a]pyrimidine derivatives and their salts exhibit an excellent antagonistic effect on slow-reacting substance of anaphylaxis and, therefore, are useable for the treatment of allergic diseases.

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Yokohama, Japan

Norihiko Kakehi