Suntory Limited

Sigma-tau Industrie Farmaceutiche Riunite S.p.a.

Norihide Amano

Teruo Amachi

Sumio Asami

Toru Nakayama

Masahiro Nakao

Hajime Yoshizumi

Yuji Shibano

Yukiko Kodama

Mitsuru Maeda

Yoshifumi Shinmen

Tohru Kodama

Takaaki Kusumi

Naoki Higuchi

Norio Iwasawa

Hidekazu Hosono

Eiichi Kosugi

Described herein are a novel heat-resistant .beta.-galactosyltransferase, a production process of the enzyme and a utilization method of the enzyme. The enzyme is produced preferably by produced by a microorganism belonging to the family of Actinomycetaceae, which may be selected from fungi belonging to the genus Saccharopolyspora, the genus Thermomonospora or the genus Thermoactinomvces.

Heat-resistant .beta.-galactosyltransferase, its production process and

Described herein are a novel heat-resistant .beta.-galactosyltransferase, a production process of the enzyme and a utilization method of the enzyme. The enzyme is produced preferably by produced by a microorganism belonging to the family of Actinomycetaceae, which may be selected from fungi belonging to the genus Saccharopolyspora, the genus Thermomonospora or the genus Thermoactinomyces.

Process for producing novel heat-resistant .beta.-galactosyltransferase

A novel peroxidase was obtained from a fast growing microorganism of the genus Coprinus cinereus. The fungal peroxidase is comparable to the conventional peroxidase derived from horseradish or Japanese radish in that it can be used either as a clinical or diagnostic reagent or as a marker enzyme in enzyme immunoassay.

Process for producing peroxidase

Novel peptide analogues which exhibit inhibitory activity against aspartic proteinases, a novel species of actinomycetous microorganism which produces said novel peptide analogues, a process for producing said novel analogues by culturing said species and a pharmaceutical composition containing said analogues.

Enzyme inhibitor and method of producing the same

A 2-pyranone derivative represented by the formula (I): ##STR1## wherein R represents a hydrogen atom, or a linear, branched alkylcarbonyloxy, or cyclo-alkylcarbonyloxy group having 3 to 10 carbon atoms, and salts thereof; a process for the production of the above-mentioned 2-pyranone derivative (I), comprising the steps of culturing a microorganism belonging to the genus Streptomyces and capable of producing the derivative, to produce the derivative, and recovering the produced derivative from the cultured product; a biocidal composition comprising the above-mentioned 2-pyranone derivative (I); and a microorganism belonging to the genus Stretromyces and capable of producing the above-mentioned 2-pyranone derivatives.

2-pyranone derivative and process for production thereof

A novel superoxide dismutase prepared from a superoxide dismutase-producing strain of the genus Nocardiopsis. The enzyme is a tetramer with a molecular weight of about 8.8.times.10.sup.4, composed of sub-units of about 2.2.times.10.sup.4. The superoxide dismutase contains 1.56 g-atoms of iron per mole but no copper or manganese. Potassium cyanide at a concentration of 1 mM does not inhibit activity, however exponential inactivation is caused by 5 mM hydrogen peroxide.

Novel superoxide dismutase and process for preparation thereof

A novel peroxidase that is non specific and that does not contain isozymes and hence, is suitable as a diagnostic reagent or as a marker enzyme in enzyme immunoassay is provided as well as a process of its preparation. The novel peroxidase is produced by a microorganism of a new genus Arthromyces.

Growing community of inventors

Takatsuki, Japan

Norihide Amano