Advanced Telecommunications Research Institute International

Noriaki Yahata

Jun Morimoto

Mitsuo Kawato

Takeo Watanabe

Kazuhisa Shibata

Yuka Sasaki

Ryuichiro Hashimoto

Nobumasa Kato

Kiyoto Kasai

Giuseppe Lisi

Hiroshi Imamizu

Megumi Fukuda

Provided is a method of analyzing brain activities for realizing a biomarker for neurological/mental disorder, based on brain function imaging. From measured data of resting-state functional connectivity MRI of a healthy group and a patient group, correlation matrix () of degree of brain activities among prescribed brain regions is derived for each subject. Feature extraction is executed by regularized canonical correlation analysis () on the correlation matrix () and attributes of the subject including a disease/healthy label of the subject. Based on the result of regularized canonical correlation analysis, by discriminant analysis () through sparse logistic regression, a discriminator () is generated.

Brain activity analyzing apparatus, brain activity analyzing method and biomarker apparatus

[Object] An object is to provide a brain activity analyzing method for realizing a biomarker using brain function imaging for neurological/mental disorders. [Solution] From data of resting-state functional connectivity MRI obtained by measuring groups of healthy subjects and patients, a correlation matrix of degrees of activities among prescribed brain regions is derived. By a sparse canonical correlation analysis (SCCA) of attributes of subjects and the correlation matrix, elements of correlation matrix that connect to canonical variables corresponding only to the diagnosis label are extracted. By sparse logistic regression (SLR) during Leave-One-Out Cross Validation of a first sum-set of elements of correlation matrix obtained as a result of feature extraction by a sparse regularized canonical correlation analysis, a second sum-set of elements of the correlation matrix is extracted. By discrimination analysis using sparse logistic regression on the second sum-set, a discriminator is generated.

Brain activity analyzing apparatus, brain activity analyzing method, program and biomarker apparatus

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Soraku-gun, Japan

Noriaki Yahata