Eisai Company, Limited

Agency of Industrial Science and Technology

Noriaki Kuwana

Shinya Abe

Shizumasa Kijima

Yoshimasa Takahara

Kenji Nakajima

Akio Sato

Kouzi Yamada

Yoshikazu Hasegawa

Tamio Kawamura

Satoru Kato

Yasunori Ikeda

Yukio Nozu

A process for the preparation of a two-functional-group-containing terpenoid having the general formula: ##STR1## in which n is an integer of from 1 to 5, R represents a hydroxymethyl, formyl or carboxyl group, and A represents the hydrogen atom, or a 2-tetrahydropyranyl, benzyl, methoxymethol or methoxyethoxymethyl group comprising the oxidation with a microorganism belonging to the genus Nocardia. Some of the terpenoids are of value as anti-ulcer agents, while others are useful as intermediates.

Two-functional-group-containing terpenoids, processes for the

Anti-ulcer composition comprising terpenoid containing two functional

A process for the preparation of a two-functional-group-containing terpen having the general formula: ##STR1## in which n is an integer of from 1 to 5, R represents a hydroxymethyl, formyl, or carboxyl group, and A represents the hydrogen atom, or a 2-tetrahydropyranyl, benzyl, methoxymethol or methoxyethoxymethyl group comprising the oxidation with a microorganism belonging to the genus Nocardia. Some of the terpenoids are of value as anti-ulcer agents, while others are useful as intermediates.

Two-functional-group-containing terpenoids

Novel desacyl-pepsidine and process for the preparation thereof comprising contacting N-acyl-pentapeptide with a bacterium which belongs to Bacillus pumilus. The new compounds are useful as pepsin-inhibitor and as intermediates for the preparation of N-acyl-pentapeptide homologues.

Process of preparing desacyl-pepsidine with bacillus pumilus

Novel process for biochemical optical resolution of 2DL-racemic compound of .alpha.-tocopherol ester or substances which contain the same, using culture broth, whole cell, or culture filtrate, which are obtained by cultivating microorganisms which possess an ability for hydrolysis of said ester. Beneficial advantage of the process resides in its low cost, simplicity and high resolution ratio.

Process for biochemical optical resolution of alpha-tocopheral

Growing community of inventors

Aichi, Japan

Noriaki Kuwana