Mitsui Petrochemical Industries, Ltd.

Mitsui Pharmaceuticals, Inc.

Noriaki Kihara

Ikuo Tomino

Hiroaki Tan

Junichi Imuta

Akira Awaya

Kazutoshi Horikomi

Akira Mizuchi

Takeshi Ishitoku

Toshiyuki Tsutsui

Toshihiro Sagane

Keiichi Yokoyama

Teruaki Mukaiyama

Katsuya Takahashi

Takumi Kitahara

Masaaki Yasuda

Tadayuki Sasaki

Tatsuyoshi Ishida

Masaharu Ishiguro

Mitsuyuki Takesue

Masaaki Kawasaki

Hidenari Nakahama

Isao Hashimoto

Takafumi Ishihara

Koji Kato

Naoya Sakamoto

Hitoshi Onishi

Daisuke Fukuoka

Takuo Nakano

Ken Ikeda

Takashi Tashiro

Joji Kamiya

Satoshi Inoki

Kiyoaki Sugi

Masaaki Ishii

Kanji Yoshihara

Aiichiro Ori

Yuichiro Kokubun

Eiichirou Hata

Hitoshi Ohnishi

Houji Kato

Yoshio Noguchi

Eiichiro Hata

Chain polyene group-containing norbornene compound and unsaturated

A novel unsaturated copolymer of ethylene comprises a random copolymer of (i) ethylene, (ii) an .alpha.-olefin of 3 to 20 carbon atoms and (iii) at least one straight chain or branched chain nonconjugated triene or tetraene having one vinyl group in the molecule, which contains 30-92% by mol of ethylene units (i), 6-70% by mol of .alpha.-olefin units (ii) and 0.1-30% by mol of triene or tetraene units (iii), and which has a molar ratio of ethylene units (i) to .alpha.-olefin units (ii) of 40/60 to 92/8 (ethylene units (i)/.alpha.-olefin units (ii)) and an intrinsic viscosity (.eta.), measured in Decalin at 135.degree. C., of 0.05 to 10 dl/g. This novel unsaturated copolymer of ethylene is excellent in weathering resistance, heat resistance and ozone resistance and has a high vulcanizing rate.

Unsaturated copolymer of ethylene and process for preparing the same

A branched polyene compound represented by the formula ##STR1## wherein f is an integer of 1-5; R.sup.1 and R.sup.2 represent hydrogen atoms or alkyl groups of 1-5 carbons; R.sup.3 represents a hydrogen atom or an alkyl group of 1-5 carbons or an alkenyl group represented by the formula ##STR2## wherein n is an integer of 1-5; R.sup.4, R.sup.5 and R.sup.6 represent hydrogen atoms or alkyl groups of 1-5 carbons; all of R.sup.1, R.sup.2, R.sup.3 are not simultaneously hydrogen atoms; and all of R.sup.4, R.sup.5 and R.sup.6 are not simultaneously hydrogen atoms.

Branched polyene compounds and production thereof

A process for preparing N,O-dialkylhydroxycarbamic acid ester which comprises reacting hydroxylamine or its salt with dihydrocarbyl carbonate in the presence of a basic compound to prepare hydroxycarbamic acid ester and subsequently alkylating this compound with an alkylating agent; a process for recovering N,O-dialkylhydroxycarbamic acid ester which comprises azeotropically distilling the ester with water from a solution containing the ester; a process for preparing N,O-dialkylhydroxylamine which comprises hydrolyzing N,O-dialkylhydroxycarbamic acid ester in an aqueous solution or a hydrous solvent in the presence of an alkali; a process for purifying N,O-dialkylhydroxylamine hydrochloride which comprises adding aldehyde or ketone to a solution of N,O-dialkylhydroxylamine hydrochloride containing O-alkylhydroxylamine hydrochloride as impurities to convert the O-alkylhydroxylamine hydrochloride into O-alkyl aldoxime or O-alkyl ketoxime and subsequently separating the N,O-dialkylhydroxylamine hydrochloride from the reaction system; and a process for separating N,O-dialkylhydroxylamine hydrochloride which comprises (i) adding benzene or alkylated benzene to an aqueous solution containing N,O-dialkylhydroxylamine hydrochloride, azeotropically removing water or a hydrochloride solution, and, subsequently (ii)adding alcohol thereto to obtain N,O-dialkylhydroxylamine hydrochloride in the form of crystal.

Process for preparing N,O-dialkylhydroxylamine, its salts or

The present invention relates to a process for the preparation, from e.g. anhydrovinblastine, of binary indole alkaloids effective as an anti-cancer drug, such as vinblastine, leurosidine, etc., wherein a trivalent iron source and hydride source are added in the presence of oxygen, thereby increasing a yield of an object compound. The yield of an object compound is improved still more by further addition, to the reaction system, of an oxalic acid ion source, malonic acid ion source, inorganic anion source, amino acid, etc.

Process for the preparation of binary indole alkaloids

Pyrimidine compound and pharmaceutically acceptable salts thereof

2,6-di-, 2,4,6-, 2,5,6-tri- or 2,4,5,6-tetra-substituted pyrimidines, and 2,6-di-substituted pyridines. These compounds are useful for treatment of neurological deseases.

Pyrimidines and their pharmaceutical acceptable salts, and their use as

Amine represented by the following formula (1), or their acid addition salts or their quaternary ammonium salts. ##STR1## The amines of formula (1) or their pharmaceutically acceptable acid addition salts or quaternary ammonium salts are useful for the treatment and prevention of heart diseases of animals, particularly arrhythima, myocardial infarction, angina pectoris and heart failure and psychoneurological diseases.

Coumaran group containing amine compounds and their acid addition salts

The present invention provides a process for preparing dihydrofuranone derivative of the formula (I): ##STR1## wherein R.sup.1 and R.sup.3 are individually lower alkyl, and R.sup.2 is hydrogen or lower alkyl, by reacting a dihydrofuranone derivative of the formula(I): ##STR2## wherein R.sup.1 is as defined above, with a malonic acid derivative of the formula (II): ##STR3## wherein R.sup.2 and R.sup.3 are as defined above, in the presence of an alkalimetal alkoxide and/or an alkalimetal hydroxide.

Process for preparing dihydrofuranone derivatives

2,6-di-, 2,4,6-, 2,5,6-tri- or 2,4,5,6-tetra-substituted pyrimidines, and 2,6-di-substituted pyridines. These compounds are useful for treatment of neurological diseases.

2,6-di,2,4,6-, 2,5,6-tri and 2,4,5,6-tetra-substituted pyrimidines,

Process for preparing polyalkyl-2-alkoxy-7-hydroxychroman derivative of the general formula (V): ##STR1## wherein R.sup.1 denotes lower primary alkyl, R.sup.2 denotes hydrogen or lower primary alkyl and R.sup.3 denotes loweralkyl, by reacting resorcin with either an aliphatic ketone of the general formula (I): ##STR2## wherein R.sup.1 and R.sup.2 are as defined above, and an alcohol of the formula (II):

Process for preparing polyalkyl-2-alkoxy-7-hydroxychroman derivatives

Disclosed is a novel .alpha.-chloroketone derivative as a synthesis intermediate of N-cyano-N'-methyl-N'-(2-((5-methyl-1H-imidazol-4-yl)methylthio)ethyl)guani dine (general name: Cimetidine) which shows an action of controlling the secretion of gastric acid and is valuable as a medicine for remedy of a gastric ulcer. This .alpha.-chloroketone derivative is prepared by reacting disulfide derivative with sulfuryl chloride and reacting the reaction product with methylvinyl ketone or by reacting a mercapto derivative with 3-chloro-3-buten-2-one.

Novel alpha-chloroketone derivative and process for preparation thereof

This invention concerns a method for the production of dimeric alkaloids, characterized by reacting of catharanthine with vindoline in the presence of Fe.sup.3+ and (1) removing or inactivating the Fe.sup.3+ and allowing the reaction product to react with a reducing agent or (2) allowing presence of oxygen and a dicarboxylic acid or a derivative thereof in the reaction system and allowing the reaction product to react with a hydride source. In accordance with this invention, such dimeric alkaloid as vinblastine, leurosidin, and 3',4'-anhydrovinblastine which are useful as antineoplastic drugs can be produced in high yields.

Method for production of dimeric alkaloids

A novel N-substituted imidazole or thioimidazole derivative and a pharmacologically acceptable acid addition salt thereof, which have a brain function-improving action, are disclosed. The derivative or salt is used as an effective ingredient of a brain function-improving medicine.

Imidazole derivatives having anti-hypoxia properties

A process for the purification of N-cyano-N'-methyl-N'-[2-{(5-methyl-1H-imidazol-4-yl)methylthio}-ethyl]guan idine, which comprises bringing a crude product of N-cyano-N'-methyl-N'-[2-{(5-methyl-1H-imidazol-4-yl)-methylthio}ethyl]guan idine into contact with activated carbon in water in the presence of an organic acid.

Process for purification of

Growing community of inventors

Yamaguchi, Japan

Noriaki Kihara