Kyowa Hakko Kogyo Co., Ltd.

Toyo Boseki Kabushiki Kaisha

Noriaki Hirayama

Hiroshi Kase

Hiroshi Sano

Katsuhiko Ando

Isao Kawamoto

Toru Yasuzawa

Satoshi Nakanishi

Joji Goto

Etsuyo Shimizu

Koji Yamada

Kunikatsu Shirahata

Makoto Morimoto

Masaji Kasai

Takahide Kishimoto

Tatsuya Tamaoki

Katsuichi Shuto

Yuzuru Matsuda

Fusao Tomita

Takao Iida

Masanori Oka

Kozo Asano

Seiji Takeshima

Masanori Fukui

Kazuyuki Iwahashi

Tadanobu Matsumura

PQQGDH having an improved substrate specificity or having an improved specific activity in an assay system using ferricyanide ion as a mediator is provided. Modified PQQGDH having the enhanced substrate specificity by introducing an amino acid mutation in a particular region of PQQGDH, and a method of enhancing the specific activity compared with a wild type in the assay system using the ferricyanide ion as the mediator by deleting, substituting, or adding one or more amino acids in an amino acid sequence of the wild type pyrroloquinoline quinone dependent glucose dehydrogenase.

Modified pyrroloquinoline quinone (PQQ) dependent glucose dehydrogenase excellent in substrate specificity

Novel physiologically active substances KS-504a, KS-504b and KS-504d having a vasodilative activity and a novel physiologically active substance KS-504e having an activity to inhibit histamine secretion are produced by culturing a microorganism of the genus Mollisia.

Novel substances KS-504a, KS-504b, KS-504d and KS-504e and process for

Novel physiologically active substances Ks-504a, KS-504b and KS-504d having a vasodilative activity and a novel physiologically active substance KS-504e having an activity to inhibit histamine secretion are produced by culturing a microorganism of the genus Mollisia.

A novel physiologically active substance K-252 having an antiallergic action is produced by culturing a microorganism of the genus Nocardiopsis.

Physiologically active substance K-252, process for producing same and

New antibacterial tetronolide compounds F-1 and F-2 are produced by fermentation of a microorganism belonging to the genus Micromonospora. The antibiotics F-1 and F-2 are accumulated in the culture liquor and are isolated therefrom respectively and the acyl derivatives of F-1 and F-2, that is, F-1-21-O-acetate, F-1-21-O-propionate, F-1-21-O-n-butylate, F-1 diacetate, F-1 dipropionate, F-2 triacetate, F-2 tripropionate and F-2 tri-n-butylate, etc., are synthesized from F-1 and F-2 by known means.

Antibiotics tetronolide compounds and process for production thereof

Growing community of inventors

Zama, Japan

Noriaki Hirayama