Schering Aktiengesellschaft

Bayer Schering Pharma Ag

Bayer Aktiengesellschaft

Bayer Pharma Aktiengesellschaft

Norbert Witowski

Pierre Wasnaire

Carsten Schmeck

Peter Kolkhof

Klemens Lustig

Hanna Tinel

Axel Kretschmer

Elisabeth Pook

Heiko Schirmer

Chantal Fuerstner

Thomas Neubauer

Ursula Krenz

Matthias Beat Wittwer

Thomas Mondritzki

Marie-Pierre Collin-Kroepelin

Hana Cernecka

Karoline Droebner

Anja Buchmueller

Guillaume Levilain

Robert Fricke

The present invention relates to prodrugs of 3-({3-(4-chlorophenyl)-5-oxo-4-[(2S)-3,3,3-trifluoro-2-hydroxypropyl ]-4,5-dihydro-1H-1,2,4-triazol-1-yl}methyl)-1-[3-(trifluoromethyl)-pyridin-2-yl ]-1H-1,2,4-triazole-5-carboxamide, 3-({3-(4-chlorophenyl)-5-oxo-4-[(2S)-3,3,3-trifluoro-2-hydroxypropyl ]-4,5-dihydro-1H-1,2,4-triazol-1-yl}methyl)-1-[2-(trifluoromethyl)-phenyl]-1H-1,2,4-triazole-5-carboxamide and 3-({3-(4-chlorophenyl)-5-oxo-4-[(2S)-3,3,3-trifluoro-2-hydroxypropyl ]-4,5-dihydro-1H-1,2,4-triazol-1-yl}methyl)-1-(3-chloropyridin-2-yl)-1H-1,2,4-triazole-5-carboxamide, to processes for the preparation of such compounds, to pharmaceutical compositions containing such compounds, and to the use of such compounds or compositions for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of renal and cardiovascular diseases.

Prodrugs of substituted triazole derivatives and uses thereof

The invention relates to a gripping edge () for a syringe with: a sleeve () with a first opening () for attachment to a barrel () of the syringe and a second opening (). The gripping edge () comprises a flange () that is attached to the sleeve () at a distance from the first opening (). A large number of catches (), which project radially toward the inside from the inside wall () of the sleeve (), are provided to engage in a groove attached to an outside surface of the barrel () or projections () and to fasten the sleeve () and, over this, the gripping edge () to the barrel (), whereby a considerable number of openings, in particular a considerable number of lengthwise openings () and/or a considerable number of transverse openings (), are cut out in the sleeve (). As a result, a locking of the gripping edge () to the barrel () in the case of lower assembly forces is possible, by which a bursting tendency of the barrel (), in particular during assembly, is considerably reduced.

Gripping edge for a syringe with improved protection against bursting

A closure piece () for a medical syringe is provided, the syringe having a syringe barrel () and a syringe neck (). The closure piece has an adapter () which can be fitted onto the syringe neck (). A screw-type closure piece () can be fitted onto the adapter (). A twist-off ring () is connected to the screw-type closure piece (). A closure cap () can be introduced into the syringe neck ().

Closure piece for medical syringe

The invention relates to a reservoir () for dispensing free-flowing substances, which comprises the following features: (a) reservoir () has flexible reservoir walls (and); (b) reservoir walls (and) are one-piece or connected to one another; (c) reservoir walls (and) form a sealed container, which has at least one opening (); (d) reservoir walls (and) are connected at least partially to at least two flat standing elements (), which are separated in the standing area of reservoir walls (and); (e) opening () has a closure (), whereby at least portions of reservoir walls (and) and/or standing elements () consist of a composite material, which (i) consists of plastic laminates, or (ii) consists of at least one plastic laminate and an aluminum laminate, here, the laminates are connected to one another. Reservoir () is provided preferably to accommodate contrast media.

Tank for administering flowable substances

A syringe with a barrel for holding a fluid medium includes a sealing cap that is put on the outlet end of the barrel. The barrel in the section that can be inserted into the cap has a first locking element on the outside. The sealing cap in the corresponding section has interactive second locking elements on the inside. The sealing cap can thus be put onto barrel with little force and thus less cracking occurs. To facilitate locking, the cap has a large number of second locking elements that are arranged peripherally. In each case, an expansion section is provided in the wall of cap between each pair of adjacent locking elements.

Syringe with a barrel having a sealing cap to hold a fluid medium within the barrel

Growing community of inventors

Wolfenbüttel, Germany

Norbert Witowski