Washington University

Other

Csl Limited

Continental White Cap, Inc.

A.e.c. Societe De Chimie Organique Et Biologique

Particle and Coating Technologies, Inc.

Norbert S Mason

Robert E Sparks

Irwin C Jacobs

Michael Center

Robert J Heilman

Pierre Autant

Curt Thies

John Cooper Cox

Andre Cartillier

Raymond Pigeon

Daniel M Carson

Mariam M Wahab

Galen G Lapka

A method of producing a fast-dissolving pharmaceutical delivery device of moderate strength. The delivery device is a fully formed tablet composed of readily available sugars, strength polymers and a volatilizable excipient along with an active ingredient and optional flavorings. The tablet as made will disintegrate in an aqueous medium such as saliva in under 15 seconds, making mastication unnecessary or at least requiring only one or two bites on the tablet. Essential to the invention is the easily obtainable particle size ranges of the sugars and the volatilizable excipient which promotes optimum release and tablet strength. The invention also allows for effective taste masking of the active ingredient with standard particle coating techniques.

Method of producing porous tablets with improved dissolution properties

Spray dried vaccine preparation comprising aluminium adsorbed immunogens

This relates to the provision of a vacuum actuated button type closure with a tamper indicating arrangement which will visually indicate when a container has been opened or more particularly when the vacuum within a vacuum packed container has been lost. The deflectable button of the closure is utilized to squeeze a dye from a sponge like member into a layer of absorbent material so as to color the absorbent material. The absorbent material, in turn, is provided with non-absorbent areas which define indicia to indicate that an associated container has been opened. The layer of absorbent material is carried by an arched cross sectional cover and in several forms of the cover, a central portion of the cover is downwardly deformable under pressure to move the layer of absorbent material from an inoperative position to a lowered position for cooperation with the sponge like member when the button returns to its up position to effect the flow of the dye from the sponge like member into the layer of absorbent material.

Tamper indicating means for vacuum closures

A composition which is stable in a medium in which the pH is greater than or equal to 5.5 and which permits the release of an active substance in a medium in which the pH is less than or equal to 3.5, comprising the active substance, which contains inclusions of, or which is completely or partially covered by, a pH sensitive material whose extent and/or rate of swelling is greater in an acidic medium than in a neutral medium, and a coating of a hydrophobic layer.

Composition for feeding ruminants

A method of melt granulation for powdery material is disclosed wherein the powdery material is discharged onto the upper surface of a heated rotary spreader for migration under centrifugal force to the periphery of the spreader accompanying by melting of a portion of the material and enrobing of non-melted particles by the melted material for discharge as enlarged granules from the periphery of the spreader. To improve the quality of the granules produced, the feed material is supplied to the spreader at two separate locations. The first location is the central portion of the spreader to provide the melted material and the second location is adjacent to the periphery of the spreader. The spreader is preferably in the form of a concave bowl or inverted truncated cone or dish. Feed material is supplied to the first location by a screw feeder extending down the side of the dish and at the second location by a rotary vaned distributor located within the dish which radially flings the feed material onto the inclined dish wall. The process and apparatus is particularly useful for the production of non-sticky granules which are difficult to form when a single central feed of material is used.

Method and apparatus for granulation and granulated product

Method and apparatus for the formation of granules of a larger size or mass of a desired range from a feed stock of smaller particles comprising feeding a meltable powdery material to be granulated, or a non-meltable powdery material with a meltable binder to the surface of a rotating spreader means in the form of a disk or bowl, at least a portion of which has been heated to a temperature above the melting point of the meltable component of the feed material wherein the rate of feeding, the energy input to the spreader means and the rotational speed of the spreader means are controlled so that there is sufficient time for at least a partial melting of the meltable component of the feed material substantially solely by contact with the heated surface of the spreader means, centrifugally spreading the material across the surface of the disk or bowl and dispersing the same from the edge thereof into an atmosphere cooler than the melting temperature to form the granulated product. For certain materials only a part of the powdery feed material is melted forming a liquid film carrying a major portion of substantially unaffected or minimally affected feed material to produce a product comprising individual granules containing a core as the major part of each granule with the original powdery material essentially unchanged maintained in self-sustaining form by a matrix of melted and resolidified particles bonded to each other at their surface.

Method for granulation

Solid particles or viscous liquid droplets of core material are encapsulated in a coating material largely as single particles with a single coherent coating, by feeding a suspension of the two materials onto a rotating surface. The suspension is centrifugally dispersed by the rotating surface into relatively large coated particles and relatively small droplets of coating material. Only the size of the droplets of unused coating corresponds to the droplets formed from atomization of the liquid coating material. The size of the coated particles depends on the size of the uncoated particles and is much less dependent upon the atomization characteristics of the rotating surface. Upon being thrown from the rotating surface, or falling from that surface, the droplets and coated particles are solidified by exposure to air and are separated by sieving, or the like. The solidified droplets of pure coating material may be recycled into the suspension. Coating of all particles is achieved by dispersing the individual components of core material in the coating material before the resulting suspension reaches the rotating surface.

Method for coating particles or liquid droplets

Microcapsules particularly those less than 300 microns in size are provided which are adapted for injection by conventional means to afford controlled release of the encapsulated drug material, such as a narcotic antagonist, an antibiotic or the like, over a prolonged period. The microcapsules are characterized by a solid core material of a solid, injectable drug material and a wall material engulfing the core material and composed of a polymer material such as a bioabsorbable polymer material. The microcapsules are made by providing a system containing a mixture of particles of a solid, injectable drug material and a solution of a bioabsorbable polymer material in a solvent in which the drug material is substantially insoluble. The system is treated to induce phase separation of the bioabsorbable polymer material from the solution by the addition to the system of a phase separation agent at a temperature at least as low as -30.degree. C. Phase separation may also be carried out at room temperature, but in either event, isolation of the microcapsules formed during the phase separation should be carried out at a temperature at least as low as -30.degree. C. The system is maintained in an agitated condition until the walls of the microcapsules constituted by the bioabsorbable polymer are substantially solidified in order to avoid aggregation or agglomeration of the microcapsules into larger capsules. The microcapsules are ready for injection, for example by being suspended in an aqueous suspending medium, upon being isolated from the system.

Process for preparation of microcapsules

The pore size distribution of a microporous separation medium, such as a membrane or gel, is modified so as to provide it with a sharp upper cut-off of preselected molecular size. The modification is effected by first filling the pores of the separation medium with a volatile liquid, and then evaporating a controlled amount of the volatile liquid to form voids at the entrances to the pores. A concentrated solution of a cross-linkable or polymerizable pore-blocking agent, such as a protein, enzyme or polymeric material, is then applied to the surface of the separation medium. The pore-blocking agent is a material which is insoluble in the volatile liquid and whose molecular size distribution has a lower limit corresponding to the preselected molecular size, whereby the pore-blocking agent selectively enters only those pores larger than the preselected size and remains in the voids at the entrances to the pores. After removing excess pore-blocking agent solution from the surface of the separation medium, the pore-blocking agent is insolublized by cross-linking or polymerization so as to immobilize it within the voids and thereby obstruct the entrances to all of the pores larger than the preselected size.

Method for modifying the pore size distribution of a microporous

Aluminum hydrogels which are stabilized at pH below 7 with a polymer containingcarboxyl groups, e.g., carboxy methyl cellulose or gum arabic. The gels are useful as phosphate binding agents in the treatment of hyperphosphatemia. Such polymers are incorporated during the formation of the aluminum hydrogel, permitting a high yield to be obtained, and preventing colloidal sol formation during exchange with monovalent anions.

Growing community of inventors

St. Louis, MO, United States of America

Norbert S Mason