Novartis Ag

Boehringer Ingelheim Pharma Gmbh & Co Kg

Merck Patent Gmbh

Norbert Rasenack

Markus Krumme

David Hook

Michael Walz

Michael Trunk

Gordon Stout

Massimo Moratto

Hagen Graebner

Joerg Ogorka

Steffen Lang

Ranjit Thakur

Fabian Weber

Hendrik Schneider

Stefan Steigmiller

Patrick Tritschler

Holger Bauer

Jim Parks

Elodia Di Renzo

Kirstin Heil

Michael Juhnke

Dilraj Singh

Bianka Kemmerer

Kerstin Ammer

Kurt Schaffluetzel

A method of preparing a pharmaceutical product comprises the steps of (a) providing a neat active pharmaceutical ingredient (API) complying with at least five of the following parameters determined by using a FT4 powder rheometer: (i) specific basic flow energy of at most 60 mJ/g; (ii) stability index of 0.75 to 1.25; (iii) specific energy of at most 10 mJ/g; (iv) major principle stress at 15 kPa of at most 40; (v) flow function at 15 kPa of at least 1.3; (vi) consolidated bulk density at 15 kPa of at least 0.26 g/mL; (vii) compressibility of at most 47%; and (viii) wall friction angle of at most 40&#xb0;; (b) dispensing the neat API of step (a) into a bottom part of a pharmaceutical carrier using a vacuum assisted metering and filling device; and (c) encapsulating the bottom part, thereby producing a pharmaceutical product.

Method for preparing a pharmaceutical product

The invention relates to a method for producing a micronized, virtually anhydrous form of (1&#x3b1;,2&#x3b2;,4&#x3b2;,5&#x3b1;,7&#x3b2;)-7-[(hydroxydi-2-thienylacetyl)oxy]-9,9-dimethyl-3-oxa-9-azoniatricyclo[3.3.1.0]nonane bromide, said form per se, and the use thereof for producing a medicament, especially a medicament having an anticholinergic effect.

Micronization method

Growing community of inventors

Weil am Rhein, Germany

Norbert Rasenack