Thermo Fisher Scientific (bremen) Gmbh

Max-planck-gesellschaft Zur F&#xf6;rderung Der Wissenschaften E. V.

Thermo Fisher Scientific Gmbh

Norbert Quaas

Stefan W Hell

Hans-Juergen Schlueter

Volker Westphal

Gerhard Jung

Ayrat Murtazin

Mikhail G Skoblin

Sebastian Geisler

Antonella Guzzonato

Tobias Wolf

Jan Rathkamp

Dirk Wohlers

Peter Huelstede

Mikhail Skoblin

A plasma source chamber () for use in a spectrometer comprises an inner housing () for accommodating a plasma source () and an outer housing () accommodating the inner housing. The outer housing () comprises at least one outer air inlet opening () in a first wall and at least one outer air outlet opening () in a second wall. Walls of the inner housing and walls of the outer housing define a spacing () so as to allow a first air flow () from the at least one outer air inlet opening () to the at least one outer air outlet opening () through the spacing () between the inner housing and the outer housing. The inner housing () comprises at least one inner air inlet opening () in a first wall and at least one inner air outlet opening () in a second wall to allow a second air flow () from the at least one inner air inlet opening to the at least one inner air outlet opening through the inner housing. Thus, an improved cooling of the outer surfaces of the plasma source chamber is achieved.

Plasma source chamber for a spectrometer

A method of determining a peak intensity in an optical spectrum is described. The method includes producing a two-dimensional array of spectrum values by imaging the optical spectrum onto a detector array. An offset using an actual location and an expected location of a peak of an interpolated subarray is used to adjust an expected location of another peak that is within another two-dimensional subarray. Interpolated spectrum values are then used to produce a peak intensity value of the second peak.

Peak determination in two-dimensional optical spectra

A method of calibrating a mass spectrometer is disclosed. The mass spectrometer includes a first quadrupole, a second mass analyzer and a detection means. The method includes calibrating the second mass analyzer at a first time, calibrating the first quadrupole at a second time later than the first including a) determining for each of several selected masses a corresponding value of the amplitude of the RF voltage and DC voltage applied to the electrodes of the first quadrupole, b) fitting a function of the selected mass to the values of the amplitude of the RF voltage and DC voltage corresponding to the several selected masses, c) detecting the selected mass in a filter window width over a mass range, d) evaluating a shift of the peak position and/or a deviation of the filter window width, and e) repeating the calibration steps under certain conditions.

Method of calibrating a mass spectrometer

A method of producing spatial fine structures comprises the steps of: selecting a luminophore from the group of luminophores displaying two different states, one of the two states being an active state in which luminescence light is obtainable from the luminophore, the other of the two states being an inactive state in which no luminescence light is obtainable from the luminophore, and the luminophore being reversibly, but essentially completely, transferable out the one state into the other state by means of an optical signal; adding the luminophore to a material; forming a spatial fine structure of the material; and fluorescence-microscopically examining whether the desired fine structure is present. The step of fluorescence-microscopically examining comprises the sub-steps of: outside measuring points of interest, transferring the luminophore into the other state with the optical signal, the luminophore being essentially completely transferred into the inactive state outside the measuring points, and measuring luminescence light only emitted by the luminophore in the active state, to even resolve lines of the fine structure at a distance of less than 100 nm.

Method of producing spatial fine structures

A method of microscopically examining a spatial fine structure comprises the steps of selecting a luminophore from the group of luminophores which have two physical states, the two states differing from each other with regard to the luminescence properties displayed by the luminophore, and which are reversibly, but essentially completely transferable out of one into the other state of their two states by means of an optical signal; overlaying a surface of the spatial fine structure with the luminophore; and determining the profile of the surface overlaid with the luminophore. The step of determining the profile of the surface comprises the sub-steps of transferring the luminophore by means of the optical signal out of the one into the other of its two states outside a presently observed measurement point, measuring luminescence light emitted by the luminophore, and repeating the sub-steps of transferring and measuring for further measurement points distributed over the surface.

Method of microscopically examining a spatial finestructure

Growing community of inventors

Bremen, Germany

Norbert Quaas