Other

Takeda Chemical Industries, Inc.

Boehringer Ingelheim Vetmedica Gmbh

Norbert Poellinger

Tomohiro Yoshinari

Shinji Maegata

Fritz Schueckler

Martin Andreas Folger

Stefan Johannes Lehner

Annette Grave

Randolph Seidler

Stefan Lehner

This application relates to taste masked multi-layered particles an inert core, one or more coating layer(s) comprising a pharmaceutically active ingredient and a binder, an intermediate coating layer (seal coating) free from a low molecular weight water-soluble ionic compound and comprising a water-soluble pharmaceutical film-forming compound selected from (i) HPMC and PEG or (ii) PVP, and an outer coating layer (final or taste masking coating) free from a low molecular weight water-soluble ionic compound and comprising (i) a poly(meth)acrylate or (ii) a mixture comprising 60-90% (w/w) EC and 10-40% (w/w) HPMC, wherein the pharmaceutically active ingredient is water-soluble and comprises either at least one basic group and/or a bitter taste. Further disclosed are methods for the production of such particles and pharmaceutical compositions comprising them.

Taste masked pharmaceutical composition

D-mannitol having a specific surface area of not less than about 1 m /g is disclosed. The D-mannitol shows improved compressibility and is useful as an excipient.

D-mannitol and its preparation

D-mannitol having a specific surface area of not less than about 1 m,/g is disclosed. The D-mannitol shows improved compressibility and is useful as an excipient.

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Muellheim, Germany

Norbert Poellinger