Egis Gyogyszergyar Rt.

Egis Gyogyszergyar Nyilvanosan Mukodo Reszvenytarsasag

Norbert Nemeth

Gyula Simig

Kalman Nagy

Gabor Blasko

Jozsef Reiter

Daniel Bozsing

Ferenc Lorant Bartha

Kálmán Nagy

Peter Tompe

Pal Vago

Gyorgy Krasznai

Zsuzsanna Szent-Királlyi

Zoltán Katona

Gyōrgy Clementis

Gyorgyi Donath Vereczkey

Gabor Nemei

Gyorgyi Lax Kovanyi

Peter Tömpe

Gyōrgyi Vereczkeyne Donath

Jozsef BARKÓCZY

Judit Cselenyak

Péter Kótay Nagy

Gyorgyi Vereczkeyn Donáth

The invention refers to a novel process for the preparation of {2-[-(&#x3b1;-phenyl-p-chlorobenzyl)piperazin-1-yl]ethoxy}acetic acid, which comprises hydrolyzing an N,N-disubstituted {2-[-(&#x3b1;-phenyl-p-chlorobenzyl)piperazin-1-yl]ethoxy}acetamide, wherein said substituents are selected from alkyl groups having 1 to 4 carbon atoms optionally substituted by a phenyl group, alkenyl groups having 2 to 4 carbon atoms or cyclohexyl groups, or the substituents together with the adjacent nitrogen atom of the acetoamido group, form a morpholino group.

Process for the preparation of {2-[4-&#x3b1;-phenyl-p-chlorobenzyl)piperazin-1-yl]ethoxy} acetic acid and novel intermediates therefor

The invention relates to a new process for the preparation of amlodipine besylate of the Formula ##STR1## Amlodipine besylate of the Formula I is a valuable known blood pressure decreasing antianginal agent. The advantage of the process of the present invention is that it can be carried out in a simple way with high yields and there is no need to isolate the amlodipine base.

Process for the preparation of a dihydropyridine derivative

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Sopron, Hungary

Norbert Nemeth