Egis Gyogyszergyar Nyilvanosan Mukodo Reszvenytarsasag

Egis Gyogyszergyar Rt.

Norbert Mesterházy

Kálmán Nagy

Györgyi Vereczkeyné Donáth

Gyula Simig

Tibor Mezei

Balázs Volk

Márta Porcs-Makkay

Gyula Lukács

Zsuzsanna Szent-Királlyi

Enikó Molnár

Gyuláné Körtvélyessy

Éva Pécsi

György Krasznay

Györgyi Vereczkeyne Donath

Valéria Hofmanné Fekete

György Krasznai

Györgyi Kovanyine Lax

Gábor Nemeth

Enikõ Molnár

The invention provides a process for the preparation of high purity meloxicam of the Formula (II). The meloxicam raw product is reacted with the solution of potassium hydroxide or potassium carbonate, whereby high purity meloxicam potassium sait monohydrate is produced. Said sait is subsequently treated with mineral or organic acid to yield high-purity meloxicam.

Process for preparation of high-purity meloxicam and meloxicam potassium salt

The invention relates to a process for the preparation of 2-methyl-4-(4-methylpiperazin-1-yl)-10H-thieno-[2,3-b][1,5]benzodiazepine (olanzapine) of the formula (I) by reacting 4-amino-2-methyl-10H-thieno[2,3-b][1/5]benzodiazepine hydrochloride of the formula (II) with N-methylpiperazine in an organic solvent, which comprises carrying out the reaction in the mixture of toluene and 1,3-dimethyl-2-imidazolidinone. The invention also encompasses new 2-methyl-4-(4-methylpiperazin-1-yl)-10H-thieno[2,3-b] [1,5]benzodiazepine dihydrochloride trihydrate of the formula (IB), the preparation thereof and pharmaceutical compositions comprising said new compound. 

Process for the preparation of olanzapine

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Szombathely, Hungary

Norbert Mesterházy