Ecole Polytechnique Federale De Lausanne

Universitè De Genève

Richard Wolf Gmbh

Photocure Asa

Norbert Lange

Georges Wagnieres

Hubert Van Den Bergh

Morten Groseth

Andrej Babic

Matthieu Zellweger

Ulf Zanger

Pavel Kucera

Patrice Jichlinski

Denis Salomon

Alexandre Marti

Andre Studzinski

Nicolas Chauvin

Nora Dögnitz

Bjørn Klem

Marino A Campo

The present invention is directed to new 5-ALA derivatives, particles and formulation thereof, related methods of preparation and methods of use thereof. In particular, the invention relates to compounds of the invention, particles and formulation thereof useful in the treatment of a cancer and/or the diagnosis of a cancer cell such as in photodynamic therapy or photodynamic diagnosis.

5-ALA derivatives and use thereof

A method for hair removal from a skin area by selective photo-inactivation of the pilo-sebaceous apparatus using derivatives of ALA with alkylene-glycol chains. Selectivity of the method is further enhanced by treatment of the epidermis by agents reducing PpIX levels in the epidermis. Side effects are diminished by using short drug/light intervals.

Method for hair removal

The invention concerns a 5-aminolevulinic acid ester (E-ALA) solution for producing a pharmaceutical preparation useful for diagnosing and/or treating tissue and/or cell pathologies by local radiation exposure using radiation emitted by a light source energy followed, in the case diagnosis, by detection of fluorescent protoporphyrin IX (Pp1X). The E-ALA concentration in the solution is less than 1% and ranges between 0.01% and 0.5%. The low E-ALA concentration in the solution increases Pp1X synthesis and homogenises its distribution in the cell layers while highly reducing the secondary toxicity for the treated cells.

Solution for diagnosing or treating tissue pathologies

The diagnosis apparatus according to the invention for the picture providing recording of fluorescing biological tissue by way of an endoscope contains a stimulation light source which beams spectral components suitable for fluorescence stimulation into the tissue through the endoscope. The fluorescent light reflected by the tissue reaches through the endoscope optics into a head piece where it is split into a green, and spacially separated from this, a red spectral component and falls each on one half of a CCD solid body of a highly sensitive black and white camera. In an electronic and processor component the video signals allocated to the green and to the red spectral component are processed into two separate processing channels in a manner such that the separately processed green-red video signals are simultaneously inputted to a color video monitor and here may be superimposed to a red-green monitor picture, which may show changes of tissue indicating disease, for example dysplasia, carcinomas in situ etc., in all organs which are endoscopically accessible.

Diagnosis apparatus for the picture providing recording of fluorescing

Growing community of inventors

Nyon, Switzerland

Norbert Lange