Council of Scientific and Industrial Research

Noor-ul Hasan Khan

Rukhsana Ilyas Kureshy

Raksh Vir Jasra

Sayed Hasan Razi Abdi

Pushpito Kumar Ghosh

Hari Chand Bajaj

Surendra Pratap Singh

Vishal Jitendrabhai Mayani

Syed Hasan Razi Abdi

Santosh Agrawal

Aasif Asharafbhai Dabbawala

Tamal Roy

Irshad Ahmad

The present invention provides an organic-inorganic hybrid chiral sorbent for chiral resolution of various racemic compounds viz. racemic mandelic acid, 2-phenyl propionic acid, diethyl tartrate, 2,2'-dihydroxy-1,1&#x2032;-binaphthalene (BINOL) and cyano chromene oxide with excellent chiral separation (enantiomeric excess, 99%) in case of mandelic acid under medium pressure column chromatography. These optically pure enantiomers find applications as intermediates in pharmaceutical industries.

Organic-inorganic hybrid chiral sorbent and process for the preparation thereof

A process for preparation of 2-phenyl ethanol by catalytic hydrogenation of styrene oxide using a catalyst consisting of Pd (II) on basic inorganic support is investigated. The present invention comprises development of new Pd based catalysts. The present method yields 2-phenyl ethanol in 98% selectivity at total conversion of styrene oxide. The present process represents an environment friendly alternative to conventionally used methods in industry and eliminates the reduction step for catalyst preparation. In the present invention the active catalyst is generated in situ during the hydrogenation of styrene oxide. In addition, Pd (II) supported catalysts do not catch fire (non pyrophoric), can be stored under ambient conditions and produce very less or no dust which makes said catalysts suitable for industrial application.

Hydrogenation of styrene oxide forming 2-phenyl ethanol

An improved catalytic process for the preparation of epoxides from alkenes using a combination of transition metal salt, an inorganic promoter and an organic additive in absence of solvent or in the presence of a solvent with commercially available hydrogen per oxide has been disclosed. Thus, styrene oxide was prepared at a kilogram scale in 86% isolated yield with purity &#x3e;95%.

Catalytic process for the preparation of epoxides from alkenes

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Bhavnagar, India

Noor-ul Hasan Khan