Curiochips

Seoul National University

University-industry Cooperation Group of Kyung Hee University

Snu Rdb Foundation

Curiosis Co., Ltd.

Noo Li Jeon

Jihoon Ko

Hyun Jae Lee

HyunJae Lee

James Yu

Byungjun Lee

Ho Young Yun

Sudong Kim

Young-Sook Son

Qing Ping Hu

Myeong Woo Kang

Su-Min Kim

Somin Lee

Minhwan Chung

Ju Hun Yeon

Disclosed is a blood-brain barrier vascular network implemented in a microfluidic chip. The blood-brain bather vascular network structure (BBB on a chip) (in vitro blood-brain bather (BBB)-on-a chip) formed in a microfluidic chip manufactured by a present manufacturing method of the in vitro blood-brain barrier (BBB)-on-a chip may reconstruct the blood-brain barrier in a real human body more similarly due to a specific cell configuration, compared to the conventional in vitro blood-brain barrier (BBB)-on-a chip, and thus may be used as a more accurate in vitro blood-brain barrier, and may be used for the development of various cellular therapeutic agents or drugs that work in the treatment of various brain diseases.

Blood brain barrier-on-a-chip

A microfluidic device in which microfluidic channels are embedded in a culture medium chamber and have open sides. The microfluidic device is patterned with a fluid moved along a hydrophilic surface due to capillary force, and the fluid may be rapidly and uniformly patterned along an inner corner path and a microfluidic channel. In the microfluidic device, the microfluidic channel is connected to facilitate fluid flow with a culture medium through open sides thereof and openings, and thus may provide a cell culture environment in which high gas saturation is maintained. In addition, several microfluidic devices formed on one common substrate are described. Such microfluidic devices may be manufactured of a hydrophilic engineering plastic by injection molding.

Microfluidic device having partially enclosed microfluidic channel and use thereof

Disclosed is a liquid patterning device and liquid patterning method. The liquid patterning device includes: a substrate having a flat bottom and a surface; at least one microstructure formed to vertically protrude from the surface of the substrate and including a plurality of unit microposts so as to have a desired shape; and a liquid mover for moving a liquid to be patterned on the surface of the substrate in another direction from one direction of the microstructure.

Liquid patterning device and method

Apparatuses, systems, and methods for generating concentration gradients of soluble molecules are disclosed herein. Devices and methods for generating in vitro blood vessels are also disclosed.

Device and method of 3-dimensionally generating in vitro blood vessels

Growing community of inventors

Seoul, South Korea

Noo Li Jeon