Northwestern University

Abbott Laboratories Corporation

Noel P Bouck

David W Dawson

Paul R Gillis

Jack Henkin

Olga Volpert

Andrew J Schneider

Susan E Crawford

Veronica M Stellmach

Peter J Polverini

Farzan Rastinejad

Deborah J Good

The present invention provides a method of inhibiting angiogenesis within a tissue by providing exogenous PEDF to cells associated with the tissue. The presence of exogenous PEDF inhibits angiogenesis within the tissue, in part by interfering with the ability of vascular endothelia to expand within the tissue. The invention also provides a method for determining the severity of a tumor be assaying for the presence of PEDF within the tumor. To facilitate the inventive methods, the present invention provides pharmaceutical compositions including sources of PEDF.

Methods and compositions for inhibiting angiogenesis

The present invention provides a method of inhibiting angiogenesis within a tissue by providing exogenous SLED to cells associated with the tissue. The presence of exogenous SLED inhibits angiogenesis within the tissue, in part by interfering with the ability of vascular endothelia to expand within the tissue. The invention also provides a method for determining the severity of a tumor be assaying for the presence of SLED within the tumor. To facilitate the inventive methods, the present invention provides pharmaceutical compositions including sources of SLED.

Antiangiogenic drug to treat cancer, arthritis and retinopathy

A method of inhibiting angiogenesis and preparations for use therein are disclosed. The preparations comprise human thrombospondin in trimer or monomer form or a fragment thereof capable of inhibiting vascularization. The method and preparations are especially applicable to the treatment of solid tumors including skin cancers for controlling tumor neovascularization and thereby arresting tumor enlargement.

Method of inhibiting angiogenesis of tumors

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Oak Park, IL, United States of America

Noel P Bouck