Hoffmann-la Roche Inc.

Hybridon, Inc.

Noel A Roberts

Cedric H Hassall

William H Johnson

John Goodchild

Peter C Roberts

John S Mills

Bruce L Frank

Robert E Kilkuskie

J Charles Craig

Brian P Tong

Raymond Jupp

Colin H Cashin

Andrew Slade

The present invention discloses synthetic oligonucleotides complementary to contiguous and noncontiguous regions of the HBV RNA. Also disclosed are methods and kits for inhibiting the replication and expression of HBV, and for treating HBV infections and associated conditions.

Oligonucleotides specific for hepatitis B virus

The present invention provides for peptide derivatives, a process for their manufacture and pharmaceutical preparations containing the same. The invention is also concerned with novel intermediates used in the manufacture of said derivatives.

Peptide derivatives

Compounds of the formula ##STR1## wherein R.sup.1, R.sup.2 and R.sup.3 each individually is hydrogen, or lower alkyl and R.sup.4 is hydroxy, lower alkoxy, aryl-(lower alkoxy), amino, mono(lower alkyl)amino or di(lower alkyl) amino, and pharmaceutically acceptable salts thereof which are useful in the treatment of degenerative joint diseases and of Wilson's disease are described.

Imidazole derivatives for treating joint diseases and Wilson's disease

The present disclosure relates to dipeptide derivatives. These novel compounds are useful as elastase inhibitors.

Dipeptide derivatives

The present disclosure relates to dipeptide derivatives. The novel compounds are useful as elastase inhibitors.

Growing community of inventors

Harpenden, United Kingdom

Noel A Roberts