Shionogi Company Limited

Zeria Pharmaceutical Co., Ltd.

Other

University of California

The University of Tokyo

Tohoku University

The University of New Mexico

Purdue Pharma L.p.

Sumitomo Electric Industries, Limited

Daifuku Co., Ltd.

Nobuyuki Tanaka

Manabu Katou

Masaaki Nagasawa

Ryu Nakao

Kazuyasu Asami

Yoshiyuki Aida

Eiichi Kojima

Masahiko Fujioka

Masafumi Iwatsu

Keisuke Tonogaki

Akira Ino

Tetsuo Nagano

Xiaoming Zhou

Hirotatsu Kojima

Osamu Nureki

Hiroshi Nishimasu

Shiro Kida

Takayoshi Okabe

Naoki Ohyabu

Ryuichiro Ishitani

Cheryl L Willman

Yusuke Tateno

Yu Hinata

Junken Aoki

Tadatsugu Taniguchi

Maria G Pallavicini

Mitsuyasu Kawaguchi

Junji Yamane

Hisashi Harada

Hideki Nakamura

Jiangchao Yao

Jianming Yu

Koji Masuda

Naoki Tsuno

Shigeyoshi Nishihara

Yutaka Shibata

Naoki Yoshikawa

Akira Kugimiya

Kevin Brown

Ichiro Maruyama

Kenji Yamawaki

Yasuhiko Kanda

Masakazu Murata

Dawit Tadesse

Chiaki Fujikoshi

Susumu Nakagawa

Kyohei Hayashi

Mado Nakajima

Nobuo Kawase

Masahide Odan

Naoki Tsuzuike

Yoshiyuki Kioi

Kouji Masuda

The present invention provides a compound of formula (1), wherein R, R, R, R, R, Rand Rare as defined in the description, which has an autotaxin inhibitory activity, a pharmaceutical composition comprising the compound as an active ingredient, and a method of prevention or treatment of a disease involving autotaxin, which is characterized by administering the compound. 

Fused pyrazole derivative having autotaxin inhibitory activity

A compound according to any one of formula (Ia) to (Ic), or its pharmaceutically acceptable salt: 

Pyrimidinone derivative having autotaxin-inhibitory activity

The disclosure relates to Substituted Piperidin-4-amino-Type Compounds of Formula (I) and pharmaceutically acceptable salts and solvates thereof wherein R, R, R, Q, Q, E, E, A, B, D, W, Z, a, b, n, and x are as defined herein, compositions comprising an effective amount of a Substituted Piperidin-4-amino-Type Compound, and methods to treat or prevent a condition, such as pain, comprising administering to an animal in need thereof an effective amount of a Substituted Piperidin-4-amino-Type Compound. 

Substituted piperidin-4-amino-type compounds and uses thereof

Disclosed is a compound which is useful as an AMPK activator. A compound represented by formula: or a pharmaceutically acceptable salt thereof,

Azabenzimidazole derivative having AMPK-activating activity

The disclosure relates to Substituted Benzimidazole-Type Piperidine Compounds of Formula (I): and pharmaceutically acceptable salts or solvates thereof, e.g., a pharmaceutically acceptable salt or solvate, wherein R, R, R, Q, W, U, A, B, Z, a, and the dashed lines are as defined herein, compositions comprising an effective amount of a Substituted Benzimidazole-Type Piperidine Compound, and methods to treat or prevent a condition, such as pain, comprising administering to an animal in need thereof an effective amount of a Substituted Benzimidazole-Type Piperidine Compound.

Substituted benzimidazole-type piperidine compounds and uses thereof

Disclosed is a compound which is useful as an AMPK activator. A compound represented by formula: 

Disclosed is a compound which is useful as an AMPK activator. A compound represented by the formula:   

Hetero ring-fused imidazole derivative having AMPK activating effect

Provided is a method for selectively demethylating a 2-methoxy group. Specifically provided is a production method of a compound represented by formula (7) below through the following reactions. 

Method for producing aminothiazole derivative and production intermediate

Disclosed is a compound which is useful as an endothelial lipase inhibitor. A pharmaceutical composition having inhibitory activity on endothelial lipase comprising a compound represented by the formula: its pharmaceutically acceptable salt, or a solvate thereof,wherein

Acetic acid amide derivative having inhibitory activity on endothelial lipase

A conveyance apparatus has a conveyance carriage for conveying a vehicle body, a vehicle-body support, a synchronous traveling carriage capable of traveling in synchronization with the conveyance carriage from a start point position to an end point position, a lifter provided with an elevating base that ascends via an aperture arranged on a floor surface of the conveyance carriage, and an elevating table for supporting an engine of an engine carrying-in carriage that stops at a fixed stop position and is lifted up to a predetermined height by the elevating base of the lifter.

Conveyance apparatus for an assembly line

The invention provides a compound which exhibits satisfactory peroral absorbability and excellent antagonistic activity against NK-1 receptor or NK-2 receptor. The compound is a benzylamine derivative represented by formula (1) or a salt thereof 

Benzylamine derivative

The present invention relates, in general, to a method of diagnosing tumorigenic mammalian cells or the propensity of a mammalian cell to become tumorigenetic. Additionally, the present invention relates to a cloned cDNA or genomic DNA for reducing the propensity of a cell to become tumorigenic or suppressing tumorigenic phenotype of a cell; a method of reducing the propensity of a cell to become tumorigenic or suppressing the tumorigenic phenotype of a cell; a method of treating a patient suffering from or predisposed to subsequent cancer development; and a method of diagnosing tumorigenic tissue of a human or tissue predisposed to become tumorigenic.

Interferon regulatory factors 1 and 2 in the diagnosis of tumorigenicity

Growing community of inventors

Osaka, Japan

Nobuyuki Tanaka