Dainippon Sumitomo Pharma Co., Ltd.

Sumitomo Dainippon Pharma Co., Ltd.

Nobuyuki Sawada

Chiang Jia Li

Hitoshi Ban

Hiroki Yamaguchi

Shingo Tojo

Manabu Kusagi

Yoshihide Ueno

Takashi Umezome

Tsuyoshi Noguchi

Kotaro Hirota

Tsuguteru Otsubo

Eiji Sugaru

The present invention pertains to an imidazolylamide derivative represented by formula (1) that exhibits an exceptional suppressive effect on cancer cell sphere formation ability and that is useful as an antitumor agent that can be administered orally, or a pharmacologically acceptable salt thereof. [In the formula, ring Qrepresents a Caryl group or the like; m represents 0, 1, 2, 3, 4, or 5; R, independently when multiple, represent(s) a halogen atom or the like; Rand Rindependently represent a hydrogen atom or the like; Wrepresents a Calkylene group (said group may be substituted by 1-3 fluorine atoms or Ccycloalkyls); Wrepresents &#x2014;NRC(O)&#x2014; or the like (where Rrepresents a hydrogen atom or Calkyl group); and ring Qrepresents a Carylgroup or the like] 

Imidazolylamide derivative

The compound of the formula (I): wherein W is a group of the following formula (VIII) binding to any possible position on the Q: Q is, together with W, a group of the formula: &#x2014;C(W)&#x2550;C(R)&#x2014;N(R)&#x2014;, etc.; Ris H or optionally substituted lower alkyl; R, R, R, and Rare independently H or optionally substituted lower alkyl; Ris optionally substituted lower alkyl, etc.; Ris H, etc.; Ris H, etc.; Ar is phenyl, etc., or a pharmaceutically acceptable salt thereof, where these compounds exhibiting &#x3b2;3-adrenoceptor-stimulating activity and being useful as a medicament for treatment of obesity, etc.

Indole, indazole, and benzazole derivative

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Fujisawa, Japan

Nobuyuki Sawada