Takeda Pharmaceutical Company Limited

Shin Nippon Biomedical Laboratories, Ltd.

Nobuyuki Miyajima

Yasushi Shintani

Koji Yoshimura

Akira Horinouchi

Kenji Takami

Ryota Ise

Syuji Sato

The present invention provides a tool for analysis of expression ofgene expression analysis tool containing a set of nucleic acids containing base sequences the same or substantially the same as two or more base sequences selected from the group consisting of the base sequences shown by SEQ ID NOs:1-14, or partial sequences thereof, and a method of analyzing the expression ofgene, including measuring a gene transcription product in asample using the tool.

Gene expressing analysis tool

The present invention aims at providing a useful and novel G protein-coupled receptor protein and DNA thereof. The G protein-coupled receptor protein of the present invention and the like, and the polynucleotides encoding the receptor protein and the like, are useful for; 1) determination of ligands (agonists); 2) preparation of antibodies and antisera; 3) construction of recombinant receptor protein expression systems; 4) development of the receptor binding assay systems using the expression systems and screening of pharmaceutical candidate compounds; 5) effecting drug design based on comparison with structurally similar ligand receptors; 6) reagents for preparation of probes and PCR primers for gene diagnosis; 7) production of transgenic animals; and 8) pharmaceutical drugs for the gene prophylaxis and gene therapy.

G protein-coupled receptor protein and DNA thereof

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Tsukuba, Japan

Nobuyuki Miyajima