Eisai Company, Limited

Eisai R&d Management Co., Ltd.

Nobuyuki Kurusu

Daisuke Shinmyo

Toshihiko Kaneko

Keigo Tanaka

Hironori Ikuta

Masashi Ito

Takao Saeki

Noboru Yamamoto

Toshimi Okada

Hironobu Hiyoshi

Mamoru Yanagimachi

Fumihiro Ozaki

Motohiro Soejima

Nobuhisa Watanabe

Kazuki Miyazaki

Yoshihiko Norimine

Hiroyuki Sugumi

Yuichi Suzuki

Yoichi Iimura

Eriko Doi

Seiji Yoshikawa

Tasuku Ishida

Shinji Hatakeyama

Kiyoaki Kobayashi

Daiju Hasegawa

Tetsuhiro Niidome

Tetsuyuki Teramoto

Manami Kimura

Yoshihisa Kaneda

Yukie Yoshikawa

Compounds represented by formula (I) and pharmaceutically acceptable salts thereof have excellent sodium channel inhibitory action and are useful as therapeutic agents and analgesics for various kinds of neuralgia, neuropathy, epilepsy, insomnia, premature ejaculation and the like. wherein Q represents ethylene, etc., R, Rand Rrepresent hydrogen, etc., Xrepresents Calkylene, etc., Xrepresents Calkylene, etc., Arepresents a 5- to 6-membered heterocyclic group, etc., and Arepresents Caryl, etc.

Bicycloamine derivatives

An excellent squalene synthase inhibitor is provided. Specifically, what is provided is a compound (I) represented by the following formula, a salt thereof or a hydrate of them. In formula (I), Rrepresents an optionally substituted vinyl group or an aromatic ring which may be substituted. Also, n is an integer of 0 to 2. Further, X, Y and Z are the same as or different from each other and each represents an optionally substituted carbon atom, or an optionally substituted nitrogen atom, sulfur atom or oxygen atom, and Y optionally represents a single bond, and when Y represents the single bond, the ring to which X, Y and Z belong is a 5-membered ring. Also in the formula, CyA represents a 5- to 14 membered non-aromatic cyclic amino group or non-aromatic cyclic amido group which may be substituted, and the non-aromatic cyclic amino group or the non-aromatic cyclic amido group optionally having an oxygen atom or a sulfur atom. Finally, W represents a chain 

N-aryl-substituted cyclic amine derivative and medicine containing the same as active ingredient

The present invention provides a novel compound having a superior calcium antagonism, in particular, a neuron-selective calcium antagonism. Namely, it provides a compound represented by the following formula, a salt thereof or a hydrate of them.In the formula, Ar indicates an optionally substituted 5- to 14-membered aromatic ring etc.; the ring A indicates any one ring selected from a piperazine, a homopiperazine, a piperidine and the like; the ring B indicates an optionally substituted Con hydrocarbon ring etc.; E indicates a single bond, a group represented by the formula &#x2014;CO&#x2014;, etc.; X indicates a single bond, an oxygen atom etc.; Rindicates a hydrogen atom, a halogen atom, a hydroxyl group etc.; and D, D, Wand Ware the same as or different from each other and each represents a single bond or an optionally substituted Calkylene chain.

Piperazine compound and pharmaceutical composition containing the compound

Quinuclidine compounds and drugs containing the same as the active ingredient

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Ibaraki, Japan

Nobuyuki Kurusu