Fujirebio Inc.

Nobuyuki Ise

Masahisa Okada

Tetsuji Tanimoto

Kazuya Omi

Katsuya Fujimura

Daisuke Nambara

Takeya Hori

The present invention enables to realize a convenient determination of a therapeutic effect of an anticancer agent on a cancer. Specifically, the present invention provides a diagnostic marker for an effect of an anticancer agent on a cancer, comprising a substance having an affinity for a fragment of an extracellular domain of c-MET; a diagnostic reagent for an effect of an anticancer agent on a cancer, comprising a substance having an affinity for a fragment of an extracellular domain of c-MET and the fragment of the extracellular domain of c-MET; and a method of testing an effect of an anticancer agent on a cancer, comprising (a) measuring a concentration of a fragment of an extracellular domain of c-MET in a biological sample from a subject, and (b) comparing the measured concentration of the fragment of the extracellular domain of c-MET with an indicator which presents a relationship between a concentration of the fragment of the extracellular domain of c-MET and the effect of the anticancer agent on the cancer.

Diagnostic marker for effect of anticancer agent

The present invention provides a methodology that can develop a more excellent anti-cancer drug than conventional ones for various cancers. Specifically, the present invention provides a method for establishing an artificial cell, comprising treating a cancer cell with an expression vector for a foreign oncogene and then culturing the cancer cell treated with the expression vector under a condition which inhibits an expression or function of an oncogene that is inherent to the cancer cell, and an established artificial cell; a method of screening an anti-cancer drug, comprising evaluating whether or not a test substance inhibits a proliferation of the artificial cell; as well as a method for identifying an oncogene, comprising treating a cancer cell with an expression vector for a test gene and then culturing the cancer cell treated with the expression vector under a condition which inhibits an expression or function of an oncogene that is inherent to the cancer cell.

Method for identifying oncogene, method for establishing oncogene-expressing cell, and method of screening oncogene targeting drug

A fused antigen in which at least two surface antigens of are fused and an assay for anti- antibodies, using the above fused antigen.

Treponema pallidum fused antigen and assay for anti-treponema pallidum antibodies using the same fused antigen

A,fused antigen in which at least two surface antigens of,are fused and an assay for anti-,antibodies, using the above,fused antigen.

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Tokyo, Japan

Nobuyuki Ise