Sysmex Corporation

Nobuyuki Ide

Tomofumi Nakada

Naoki Nishiyama

Megumi Goto

Keiko Higuchi

Hirotaka Abo

A method for measuring a viral antigen using a capture antibody and a detection antibody. The method includes forming a sandwich immune complex that contains the capture antibody, the viral antigen and the detection antibody. The capture antibody includes specific sequences of CDRs and the detection antibody includes specific sequences of CDRs.

Method for measuring viral antigen in sample, antibody set, and reagent kit

Disclosed is a method for producing a modified antibody, comprising: in a heavy chain of the antibody, changing at least one amino acid residue selected from the group consisting of 8th to 11th amino acid residues based on Kabat method to a cysteine residue, and changing at least one amino acid residue selected from the group consisting of 109th and 110th amino acid residues based on IMGT method to a cysteine residue; and recovering the modified antibody.

Method for improving thermal stability of antibody and method for producing modified antibody

Disclosed is a method for producing an alkaline phosphatase fusion antibody, comprising: culturing a cell comprising an expression vector comprising a gene encoding alkaline phosphatase derived from bovine small intestine orbacterium and a gene encoding an antibody in a medium comprising a zinc ion, and acquiring an alkaline phosphatase fusion antibody expressed by the cell.

Alkaline phosphatase fusion antibody and method for producing the same, and immunoassay method

Disclosed is an antibody in which the 80th amino acid residue in a variable region based on the Kabat method and the 171th amino acid residue in a constant region based on the Kabat method are substituted with cysteine in an antibody in which the 80th amino acid residue in the variable region and the 171th amino acid residue in the constant region are not cysteine.

Growing community of inventors

Kobe, Japan

Nobuyuki Ide