Chugai Seiyaku Kabushiki Kaisha

Nobuyuki Hori

Hirotaka Kashiwagi

Satoshi Tsuchiya

Masahiro Nishimoto

Atsushi Matsuo

Yoshikazu Nishimura

Satoshi Tanida

Masahide Aoki

Shoshin Yoshida

Kyoko Oguri

Hiroko Ogawa

Takahiro Kawai

Takuma Kamon

Tsutomu Sato

Hitoshi Yoshino

Yoshiyuki Furuta

Takuya Shiraishi

Naoki Okamoto

Yoshiyuki Ono

Atsushi Kimbara

Kenichi Nomura

Eisaku Mizuguchi

Kazutaka Tachibana

Yoshihito Ohtake

Shota Tanaka

Yoshihisa Murata

Takeo Harada

Shuichi Ohtomo

Naoshi Horiba

Yasuhiro Ichida

Mitsuaki Ide

The present invention provides a compound having the basic structure shown by Formula (I) in which the indole ring and the pyrazolopyridine structure is bound through a substituent, a salt thereof or a solvate of either the compound or a salt of the compound, as well as a preventative agent or a therapeutic agent for non-insulin-dependent diabetes mellitus (Type 2 diabetes) or obesity containing such compound, salt or solvate as an active ingredient.

Pyrazolopyridine derivative having GLP-1 receptor agonist effect

The present invention provides the compound, 3-[(1S,2S)-1-[5-[(4S)-2,2-Dimethyloxan-4-yl]-2-[(4S)-2-(4-fluoro-3,5-dimethylphenyl)-3-[3-(4-fluoro-1-methylindazol-5-yl)-2-oxoimidazol-1-yl]-4-methyl-6,7-dihydro-4H-pyrazolo[4,3-c]pyridine-5-carbonyl]indol-1-yl]-2-methylcyclopropyl]-4H-1,2,4-oxadiazol-5-one, or a pharmaceutically acceptable salt of the compound, as well as a preventative agent or a therapeutic agent for non-insulin-dependent diabetes mellitus (Type 2 diabetes) or obesity containing such compound.

The present invention provides a dihydropyridazine-3,5-dione derivative or a salt thereof, or a solvate of the compound or the salt, a pharmaceutical drug, a pharmaceutical composition, a sodium-dependent phosphate transporter inhibitor, and a preventive and/or therapeutic agent for hyperphosphatemia, secondary hyperparathyroidism, chronic renal failure, chronic kidney disease, and arteriosclerosis associated with vascular calcification comprising the compound as an active ingredient, and a method for prevention and/or treatment.

Dihydropyridazine-3,5-dione derivative and pharmaceuticals containing the same

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Shizuoka, Japan

Nobuyuki Hori